…a fully functional and accurate pre-clinical environment in which to conduct minibeam radiotherapy studies, SARRP is helping scientists determine best practices for delivering maximally effective cancer radiation treatments with minimal…
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Xstrahl in Action: Distinct Biochemical and Temporal Changes in Irradiated Human Breast Adenocarcinoma Xenografts
Radiation therapy plays a crucial role in the management of breast cancer. However, current standards of care have yet to accommodate patient-specific radiation sensitivity. Raman spectroscopy is promising for applications…
Xstrahl in Action: SARRP used in functional imaging integration study
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability…
Xstrahl in Action: Importance of dosimetry protocol for cell irradiation on a low X-rays
…parameters defined in dosimetry protocol for physical dose and biological outcomes. Once all parameters of the configuration were defined, dosimetry measurements with ionization chambers and EBT3 films were performed to…
Xstrahl in Action: SARRP Utilized in Pencil Minibeam Radiotherapy Study
…to 0.5mm in diameter, along with adaptable beam energy and filtration. The SARRP also easily keeps all other experiment parameters constant. See the full study at https://pubmed.ncbi.nlm.nih.gov/31483811/ View Fullscreen ×…
Xstrahl in Action: SARRP and XenX Enable Microbeam Radiation Therapy at a Small Animal Irradiator
In the study, Establishment of Microbeam Radiation Therapy at a Small Animal Irradiator, the dual focal spot and adjustable photon energy of the XenX x-ray tube allowed optimization of the…
Xstrahl in Action: Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction
…rats. TEM analysis showed decreased myelination, increased microvascular damage, and progressive axonal atrophy of the CN fibers after RT. Electrophysiologic analysis showed significant impairment of the CN conduction velocity after…
Xstrahl in Action: Inhibition of ataxia telangiectasia related-3 improves therapeutic index
Cancer treatment has come a long way in a short time, however as new drugs and treatments are developed, the therapeutic index of treatments needs to be assessed. In their…
Xstrahl in Action: SARRP used in whole brain versus targeted dentate gyrus irradiation models
…strategy has been twofold endorsed. The millimetric ballistic specificity of our models was first validated by measuring gamma-H2AX increase after irradiation. They then demonstrated higher anxiety/depressive-like behavior, preferentially mediate by…
Xstrahl in Action: SARRP used in Mouse Prostate Nestin study
…SARRP have demonstrated that Nestin/NG2 expression marks “a novel radioresistant prostate stem cell that is active during development and displays reserve stem cell activity for tissue maintenance.” Essentially, the study…