Mutations of the phosphatase and tensin homolog (PTEN) gene can affect cancer development and cause large hamartomatous skin change in sun-exposed areas. Radiotherapy has reportedly caused increased acute toxicity for…
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Xstrahl in Action: SARRP Helps Research Team Validate Success of New Proton FLASH RT System
…to configuring a highly targeted experiment where accuracy is of the utmost importance. Furthermore, SARRP offers the flexibility researchers need to adapt RT delivery mechanisms to suit custom research requirements.[:]…
Xstrahl participates in ASTRO 59th annual meeting
…Micro-Irradiator, the most advanced system available for pre-clinical radio biology research. ASTRO gave the industry a chance to experience a number of new and updated accessories, including MuriGlo. MuriGlo has…
Xstrahl Introduces Monte Carlo Dose Engine for Fast and Precise Calculations
August 26th, 2019 Xstrahl Life Science, global leader in advanced radiation research systems, is introducing a Monte Carlo dose engine to enable comparative research work to be carried out on…
MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP).
…animals showed no significant tumor growth from 2 to 9 days post RT. γH2AX results confirmed the accuracy of dose delivery. This model, which is quite similar to the approach…
Preclinical Models for Translational Research Should Maintain Pace With Modern Clinical Practice.
…important initial shift toward target-directed treatment (1). Treatment planning accuracy was further increased by fusing CT planning images with positron emission tomography (PET) and magnetic resonance imaging (MRI) scans (2,…
An integrated x-ray/optical tomography system for pre-clinical radiation research.
The current Small Animal Radiation Research Platform (SARRP) is poor for localizing small soft tissue targets for irradiation or tumor models growing in a soft tissue environment. Therefore, an imaging…
Xstrahl in Action: SARRP used in preclinical evaluation of lung toxicity study
…for single and fractionated exposures in directly targeted volumes. Responses observed outside the target volume were attributed to nontargeted effects and showed no dependence on either mean lung dose or…
An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse
…was still used for dose calculations, target identification was based on MRI. Each step of the radiotherapy planning procedure was validated initially in vitro using BANG gel dosimeters. Subsequently, MR-IGRT…
An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma
Background The radiopharmaceutical 131I-meta-iodobenzylguanidine (131I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from 131I-MIBG is likely to be obtained by its combination with chemotherapy. We previously reported…