Life Sciences
Publications

Publications

The below purple dropdown reveals a live list of Xstrahl Life Sciences publications that will be updated on an ongoing basis. Stay tuned to our twitter (@XstrahlLifeSci) and Newsfeed to find out the latest papers being published.

CLICK HERE for a full list of the 70 plus papers that have been published with the assistance of the Xstrahl SARRP system. 

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SARRP Publications
  1. A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies. Ethel J. Ngen , Lee Wang , Nishant Gandhi, Yoshinori Kato, Michael Armour, Wenlian Zhu, John Wong, Kathleen L. Gabrielson, Dmitri Artemov. Journal of Neuro-Oncology. June 2016, Volume 128, Issue 2, pp 225-233. Download Paper
  2. Radiation Therapy Induces Macrophages to Suppress Immune Responses Against Pancreatic Tumors in Mice. Lena Seifert, Gregor Werba, Shaun Tiwari, Nancy Ngoc Giao Ly, Susanna Nguy, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Donnele Daley, Rocky Barilla, Daniel Tippens, Alejandro Torres-Hernandez, Mautin Hundeyin, Vishnu Mani, Cristina Hajdu, Ilenia Pellicciotta, Philmo Oh, Kevin Du, George Miller. Gastroenterology. June 2016. Volume 150, Issue 7, Pages 1659–1672.e5
  3. Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction. Joseph J. Janicki, Michael B. Chancellor, Jonathan Kaufman, Michele A. Gruber and David D. Chancellor. Toxins (Basel). March 2016; 8(3): 81. Download Paper
  4. NF-kB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor supression. Priscilla S. Simon1,4,6, Kankana Bardhan1, May R. Chen1, Amy V. Paschall1,4,6, Chunwan Lu Roni J. Bollag Feng-Chong Kong JianYue Jin Feng-Ming Kong Jennifer L. Waller Raphael E. Pollock and Kebin Liu. OncoTarget. March 2016. DOI: 10.18632/oncotarget.8246 Download Paper
  5. Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research. Bin Zhang, PhD, Ken Kang-Hsin Wang, PhD, Jingjing Yu, PhD, Sohrab Eslami, PhD, Iulian Iordachita, PhD, Juvenal Reyes, MD, Reem Malek, PhD, Phuoc T. Tran, MD, PhD, Michael S. Patterson, PhD, and John W. Wong, PhD. Int J Radiat Oncol Biol Phys. April 2016. 1;94(5):1144-53. doi: 10.1016/j.ijrobp.2015.11.039. Epub 2015 Dec 14. Download Paper
  6. Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape. Sanmay Bandyopadhyay, Thomas J. Quinn, Lisa Scandiuzzi, Indranil Basu, Ari Partanen, Wolfgang A. Tome´, Fernando Macian, and Chandan Guha. Journal of Immunology. Feb 2016. 15;196(4):1964-76. doi: 10.4049/jimmunol.1500541. Download Paper
  7. Quantitative correlational study of microbubble-enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model. Xiaohua Hong, Li Liu, Meiyun Wang, Kai Ding, Ying Fan, Bo Ma, Bachchu Lal, Betty Tyler, Antonella Mangraviti, Silun Wang, John Wong, John Laterra, and Jinyuan Zhou. Neuro-Oncology. Dec 2015. 42(8):4762-72. Download Paper
  8. MRI-Only Based Radiotherapy Treatment Planning for the Rat Brain on a Small Animal Radiation Research Platform (SARRP). Shandra Gutierrez*, Benedicte Descamps, Christian Vanhove. PLOS ONE. Dec 2015. 3;10(12):e0143821. Download Paper
  9. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity, Ramesh Rengan, Kristen E. Pauken, Erietta Stelekati, Joseph L. Benci, Bihui Xu, Hannah Dada, Pamela M. Odorizzi, Ramin S. Herati, Kathleen D. Mansfield, Dana Patsch, Ravi K. Amaravadi, Lynn M. Schuchter, Hemant Ishwaran, Rosemarie Mick, Daniel A. Pryma, Xiaowei Xu, Michael D. Feldman, Tara C. Gangadhar, Stephen M. Hahn E. John Wherry, Robert H. Vonder heide & Andy J. Minn. Nature. March 2015. Nature 520, 373–377 (16 April 2015). Download Paper
  10. A multipurpose quality assurance phantom for the small animal radiation research platform (SARRP). Wilfred Ngwa, Panagiotis Tsiamas, Piotr Zygmanski, Mike Makrigiorgos and Ross I Berbeco. Physics in Medicine and Biology. May 7 2012; 57(9): 2575-86. Download Paper 
  11. An integrated method for reproducible and accurate image guided stereotactic cranial radiation of brain tumors using the small animal radiation research platform. Brian C. Baumann, Joseph L. Benci, Phillip P. Santoiemma, Sanjay Chandrasekaran, Andrew B. Hollander, Gary D. Kao and Jay F. Dorsey. Journal of Translational Oncology. Aug 2012; 5(4): 230-7. Download Paper 
  12. An integrated x-ray/optical tomography system for pre-clinical radiation research. S. Eslami ; Y. Yang ; J. Wong ; M. S. Patterson ; I. Iordachita. March 2013. Journal of Medical Imaging. V: 8668, 866830-866830-9. Download Paper
  13. Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas. Jing Zeng, Alfred P. See, Jillian Phallen, Christopher M. Jackson, Zineb Belcaid, Jacob Ruzevick, Nicholas Durham, Christian Meyer, Timothy J. Harris, Emilia Albesiano, Gustavo Pradilla, Eric Ford, John Wong, Hans-Joerg Hammers, Dimitris Mathios, Betty Tyler, Henry Brem, Phuoc T. Tran, Drew Lardoll, Charles G. Drake, Michael Lim JHU. International Journal of Radiation Oncology Biology Physics. Jun 2013. 1;86(2): 343-9. Download Paper
  14. Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice. Daniel A. Lee, Sooyeon Yoo, Thomas Pak, Juan Salvatierra, Esteban Velarde, Susan Aja, and Seth Blackshaw. Frontiers Neuroscience. June 2014; 8: 157. Download Paper
  15. Dose Painting with a Variable Collimator with the Small Animal Radiation Research Platform (SARRP). Nathan B. Cho, John Wong and Peter Kazanzides. The MIDAS Journal. Image-Guided Adaptive Radiation Therapy (IGART) 2014. Download Paper
  16. Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization. Ajlan Al Zaki, Daniel Joh, Zhiliang Cheng, Andre´ Luı´s Branco De Barros, Gary Kao, Jay Dorsey, And Andrew Tsourkas. ACS Nano. ACS Nano. 2014 Jan 28;8(1):104-12. Download Paper
  17. Hedgehog Pathway Inhibition Radiosensitizes Non-Small Cell Lung Cancers. Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake T. Aftab, Michael Armour, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, and Russell K. Hales. International Journal of Radiation Oncology Biology Physics. Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):143-9. Download Paper
  18. Hematopoietic Stem and Progenitor Cell Migration After Hypofractionated Radiation Therapy in a Murine Model. Jonathan Kane, Sarah A. Krueger, Joshua T. Dilworth, John T. Torma, George D. Wilson, Brian Marples, and Gerard J. Madlambayan. International Journal of Radiation Oncology Biology Physics. Int J Radiat Oncol Biol Phys. Volume 87, Issue 5 , Pages 1162-1170, 1 December 2013. Download Paper
  19. Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair. David M. Guttmann, Lori Hart, Kevin Du, Andrew Seletsky, Constantinos Koumenis. International Journal of Radiation Oncology Biology Physics. Int J Radiat Oncol Biol Phys Volume 87, Issue 1 , Pages 168-175, 1 September 2013. Download Paper
  20. Mechanisms of blood flow and hypoxia production in rat 9L-epigastric tumors. Koch C, Jenkins WT, Jenkins KW, Yang XY, Shuman AL, Pickup S, Riehl CR, Paudyal R, Poptani H, Evans SM. Tumor Microenvironment and Therapy.  Tumor Microenvironment and Therapy. Volume 1, Pages 1–13, ISSN (Online) 2299-1123. Download Paper
  21. microRNA-34a promotes DNA damage and mitotic catastrophe. Alexander V Kofman, Jungeun Kim, So Yeon park, evan Dupart, Christopher Letson, Yongde Bao, Kai Ding, Quan Chen, David Schiff, James Larner, and Roger Abounader. Cell Cycle. Cell Cycle. 2013 Nov 15;12(22):3500-11. Download Paper
  22. Modality comparison for small animal radiotherapy: A simulation study. Magdalena Bazalova, Geoff Nelson, John M. Noll, and Edward E. Graves. Medical Physics. Med Phys. 2014 Jan;41(1):011710. Download Paper
  23. MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP). Bolcaen J, Descamps B, Deblaere K, Boterberg T, Hallaert G, Van den Broecke C, Decrock E, Vral A, Leybaert L, Vanhove C, Goethals I. Journal of Neuro-Oncology. J Neurooncol. November 2014, Volume 120, Issue 2, pp 257-266. Download Paper
  24. Preclinical Models for Translational Research Should Maintain Pace With Modern Clinical Practice. Joshua T. Dilworth, Sarah A. Krueger, George D. Wilson, and Brian Marples.  Int J Radiation Oncol Biol Phys, Vol. 88, No. 3, pp. 540 e 544, 2014. International Journal of Radiation Oncology Biology PhysicsDownload Paper
  25. Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer. Kyle R. Cron, Kaya Zhu, Deepa S. Kushwaha, Grace Hsieh, Dmitry Merzon, Jonathan Rameseder, Clark C. Chen, Alan D. D’Andrea, David Kozono. PLOS ONE. PLoS One. 2013 Sep 5;8(9):e73710. Download Paper
Cabinet Publications
  1. Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro. Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler. The Journal of Gene Medicine. Feb 2009; 11(2): 169-79. Download Paper
  2. Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, and Laure Marignol. Radiation Research. Oct 2009; 172(4): 405-13. Download Paper

  3. Alterations in DNA Repair Efficiency are Involved in the Radioresistance of Esophageal Adenocarcinoma. Niamh Lynam-Lennon, John V Reynolds, Graham P Pidgeon, Joanne Lysaght, Laure Marignol, and Stephen G Maher. Radiation Research. Dec 2010; 174(6): 703-11. Download Paper
  4. MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. Niamh Lynam-Lennon, John V Reynolds, Laure Marignol, Orla M Sheils, Graham P Pidgeon and Stephen G Maher. Journal of Molecular Medecine. Dec 2012; 90(12): 1449-58. Download Paper

  5. Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells. Derek Hennessey, Lynn Martin, Anne Atzberger, Thomas Lynch, Donal Hollywood and Laure Marignol. Urologic Oncology. Oct 2013; 31(7): 1106-16. Download Paper
  6. DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells. Lynn Martin, Brian Marples, Anthony M Davies, Anne Atzberger, Connla Edwards, Thomas Lynch, Donal Hollywood and Laure Marignol. Cancer Letters. Jul 10 2013; 335(1): 19-25. Download Paper

  7. Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells. H Lawlor, Armelle Meunier, Niamh McDermott, Thomas Lynch and Laure Marignol. Tumour Biology. Aug 2015; 36(8): 6019-28. Download Paper

  8. Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase. Ross Carruthers, Shafiq U Ahmed, Karen Strathdee, Natividad Gomez-Roman, Evelyn Amoah-Buahin, Colin Watts and Anthony J Chalmers. Molecular Oncology. Jan 2015; 9(1): 192-203. Download Paper

  9. Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells. Shafiq U Ahmed, Ross Carruthers, Lesley Gilmour, Salih Yildirim, Colin Watts and Anthony J Chalmers. Cancer Research. Oct 15 2015; 75(20): 4416-28. Download Paper

  10. Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation. Mahmoud Toulany, Tim-Andre Schickfluß, Wolfgang Eicheler, Rainer Kehlbach, Birgit Schittek and H Peter Rodemann. Breast Cancer Research. Mar 10 2011 ;13(2): R28.Caspase-2 is required for DNA damage-inducedexpression of the CDK inhibitor p21 Download Paper

  11. WAF1/CIP1. D Sohn, W Budach and R U Jänicke. Cell Death and Differentiation. Oct 2011; 18(10): 1664-74. Download Paper

  12. Courtship raises male fertilization success through post-mating sexual selection in a spider. Jutta M Schneider and Kristiani Lesmono. Proceedings of the Royal Society B: Biological Sciences. Sep 7 2009; 276(1670): 3105-11. Download Paper

  13. Irradiation-Induced Up-Regulation of HLA-E on Macrovascular Endothelial Cells Confers Protection against Killing by Activated Natural Killer Cells. Isabelle Riederer, Wolfgang Sievert, Günther Eissner, Michael Molls and Gabriele Multhoff. PLoS ONE. Dec 16 2010; 5(12): e15339. Download Paper

  14. Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death. Denise Tischner, Jennifer Theiss, Anna Karabinskaya, Jens van den Brandt, Sybille D Reichardt, Ulrike Karow, Marco J Herold, Fred Lühder, Olaf Utermöhlen, and Holger M Reichardt. The Journal of Immunology. Nov 1 2011; 187(9): 4509-16. Download Paper

  15. Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation. Nicole Grosse, Andrea O Fontana, Eugen B. Hug, Antony Lomax, Adolf Coray, Marc Augsburger, Harald Paganetti, Alessandro A Sartori, and Martin Pruschy. International Journal of Radiation. Oncology*Biology*Physics. Jan 1 2014; 88(1): 175-81. Download Paper

  16. Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1a. Daniela Schilling, Christine Bayer, Wei Li, Michael Molls, Peter Vaupel and Gabriele Multhoff. PLoS ONE. 2012; 7(2): e31110. Download Paper

  17. Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. Sabrina Köcher, Thorsten Rieckmann, Gabor Rohaly, Wael Y Mansour, Ekkehard Dikomey, Irena Dornreiter, and Jochen Dahm-Daphi. Nucleic Acids Research. Sep 2012; 40(17): 8336–8347. Download Paper

  18. Delta-Like Ligand 4–Notch Blockade and Tumor Radiation Response. Stanley K Liu, Saif A S Bham, Emmanouil Fokas, John Beech, Jaehong Im, Song Cho, Adrian L Harris and Ruth J Muschel. Journal of the National Cancer Institute. Dec 7 2011; 103(23): 1778-98. Download Paper

  19. Cellular Autofluorescence following Ionizing Radiation. Dörthe Schaue, Josephine A Ratikan and Keisuke S Iwamoto. PLoS ONE. 2012; 7(2): e32062. Download Paper

  20. Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality. Yanyan Jiang, Tom Verbiest, Aoife M Devery, Sivan M Bokobza, Anika M Weber, Katarzyna B Leszczynska, Ester M Hammond and Anderson J Ryan. International Journal of Radiation Oncology*Biology*Physics. Jun 1 2016; 95(2): 772-81. Download Paper

  21. Listeria monocytogenes Dampens the DNA Damage Response. Ascel Samba-Louaka, Jorge M Pereira, Marie-Anne Nahori, Veronique Villiers, Ludovic Deriano, Mélanie A Hamon and Pascale Cossart. PLoS Pathology. Oct 23 2014; 10(10): e1004470. Download Paper

  22. The effect of irradiation on tumor microenvironment and bone marrow cell migration in a pre-clinical tumor model. Jonathan L Kane, Sarah A Krueger, Alaa Hanna, Thomas R Raffel, George D Wilson, Gerard J Madlambayan and Brian Marples. International Journal of Radiation Oncology*Biology*Physics. Apr 2016. Download Paper