Publication/study: “Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate” Authors: Hanoun M, Arnal-Estapé A, Maryanovich M, & H.Zahalka A Key Findings: A group of researchers using SARRP have demonstrated that Nestin/NG2 expression marks “a...
Publication/Study: Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity Authors: DeVorkin L, Pavey N, Carleton G, Comber A, et al Key Findings: While autophagy is a necessary process to ensure appropriate infection response in cells,...
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects...
Evaluation of the consequences of low to moderate doses of ionizing radiation (IR) remains a societal challenge, especially for children exposed to CT scans. Appropriate experimental models are needed to improve scientific understanding of how exposure of the...
Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and in their paper “Lung Stereotactic Arc Therapy in...
In their paper “Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field” Ghita M1, Dunne VL, McMahon SJ, Osman SO, Small DM, et al, aim to define the dose and dose-volume relationship of radiation-induced pulmonary toxicities...
Dosimety radiobiology experiemtns have long needed a viable and realistic mouse phantom. In their paper “Technical Note: Manufacturing of a realistic mouse phantom for dosimetry of radiobiology experiments.” Esplen N, Alyaqoub E & Bazalova-Carter M aim to design a...
In their paper “Characterization of a plastic scintillating detector for the Small Animal Radiation Research Platform (SARRP)” Johnstone CD, Therriault-Proulx F, Beaulieu L & Bazalova-Carter M aimed to characterize a small plastic scintillator developed for high...
Non-ablative or mild hyperthermia (HT) has been shown in preclinical and clinical studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most preclinical in vivo HT studies use subcutaneous tumor models which do not adequately...
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