DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and…
SEARCH
Search Results
Immunotherapy and SARRP; a breakthrough investigation using a clinically relevant model to yield clinically relevant data
…the tumor microenvirionment which recruits inflammatory monocytes and macrophages which ultimately promote resistance to radiotherapy. When combining RT and antibodies against CCL2, a significant decrease in inflammatory monocyte recruitment was…
Xstrahl in Action: SARRP Used for Research into Craniospinal Irradiation for Very-High-Risk Medulloblastoma
Craniospinal irradiation (CSI) is a crucial component of treatment for medulloblastoma (MB), a brain tumor clinically stratified into prognostically distinct molecular subgroups. Preclinical models of clinically relevant CSI offer the…
Xstrahl in Action: BioXmark for high-precision radiotherapy in an orthotopic pancreatic tumor mouse model
…control mice. BioXmark® enabled an exact fusion with the original treatment plan with less hardening artefacts and minimized the application of contrast agent for fractionated radiotherapy. Therefore, it was concluded…
Xstrahl in Action: SARRP Used for Research into Mebendazole Use for Malignant Meningiomas
…radiotherapy, but about 33% of patients have recurrent tumors, sometimes as a higher grade. Recently, the brain penetrant anthelmintic drug, mebendazole, has shown promise as an anticancer agent in rodent…
Evaluation of Radiation Therapy of Ocular Tumours
Xstrahl in Action A recent study investigated reduced risk of damage to nearby organs during the treatment of ocular tumours. using our Small Animal Radiation Research Platform (SARRP). Publication Orthovoltage…
Xstrahl in Action: SARRP used in designing of hyper realistic mouse phantom for dosimetry experiments
…organs manually segmented and contoured. The resulting geometries were converted into a stereolithographic file format (STL) and sent to a multimaterial 3D printer. The phantom was split into two parts…
Xstrahl in Action: Small field dosimetry for the small animal radiotherapy research platform (SARRP)
…radiation beams (soft X-ray and charged particles) have long been used to deliver radiation to specific subcellular compartments. However, as dosimetry, these tools mostly use different particle counters to calculate…
Xstrahl in Action: SARRP Assists in Preclinical Dose Verification Using 3D Printed Mouse
…researchers successfully use the 3D printed mouse to obtain “accurate dose estimates for a variety of preclinical treatment paradigms”, but they also found that the use of these phantoms could…
Xstrahl in Action: SARRP used in mild hyperthermia as a localized radiosensitizer study
…combination treatment group compared to the other treatment groups. These early results demonstrate the successful use of external mild HT as a localized radiosensitizer for deep-seated tumors. This…