Glioblastoma (GB) is the most common primary malignant brain tumor in adults. The standard of care consists of maximal possible surgical resection with concomitant radiation therapy (RT) and temozolomide (TMZ)….
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Dosimetric Validation of SmART-RAD for X-ray Cabinet Radiobiology Irradiators
…agreement with measured depth dose distributions in phantoms containing both water and bone equivalent materials, and good agreement with measured 3D dose distributions Good spatial and dosimetric agreement between simulated…
Xstrahl in Action: Orally Bioavailable ATM Inhibitor Radiosensitizes Intracranial Gliomas
Inhibition of ataxia-telangiectasia mutated (ATM) during radiotherapy of glioblastoma multiforme (GBM) may improve tumor control by short-circuiting the response to radiation-induced DNA damage. A major impediment for clinical treatment is…
Identifying Tumors in Hard to See Places…
…10% of the mice that underwent surgery. The authors of the present study reference this observation in the full manuscript and expand on the fact that no animals were lost…
Xstrahl In Action: Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies
…the limited and expensive beamtime at synchrotrons. In the paper “Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept” Y. Prezado, M. Dos…
SARRP used in ER+ Breast Cancer Treatment Research
In the recent study, Radiotherapy Delivered Before CDK4/6 Inhibitors Mediates Superior Therapeutic Effects in ER+ Breast Cancer, researchers compared various forms of treatment including radiotherapy, oral palbociclib, or a combination…
Xstrahl in Action: External beam hepatic irradiation for robust liver repopulation
…using the Xstrahl SARRP, targeting the median and right lobes that enhance cell transplant engraftment and repopulation of the liver in ApoE-deficient mice when combined with administration of the hepatic…
SARRP Used to Compare Radiotoxicity in Glioblastoma Radiation
In the study, Differential Effects of Radiation Fractionation Regimens on Glioblastoma, researchers compared radiation regimens for glioblastomas, and their radiotoxicity and neurocognitive effects. SARRP was used for in vivo and…
Xstrahl in Action: Combining radiation with hyperthermia: a multiscale model
Cancer is a complex disease, with a variety of approaches available for its treatment. Treatment modalities are often combined to maximize response and to overcome the limitations of individual modalities…
Xstrahl in Action: Dosimetric and Geometric Characteristics of Image‐Guided Irradiators using 3D Dosimetry
…included percent depth dose (PDD) curves and beam profiles. For geometric evaluation, the isocenter sizes of the treatment stage and gantry rotations as well as their coincidence were measured using…