…to identify lung nodules using the SARRPs on-board, high resolution, cone beam CT capabilities. This allowed them to target peripheral lung nodules using Muriplan software while avoiding off-target nodules in…
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Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer
Purpose To implement clinical stereotactic body radiation therapy (SBRT) using a small animal radiation research platform (SARRP) in a genetically engineered mouse model of lung cancer. Methods and Materials A…
Proposal for a Simple and Efficient Monthly Quality Management Program Assessing the Consistency of Robotic Image-Guided Small Animal Radiation Systems
Modern pre-clinical radiation therapy (RT) research requires high precision and accurate dosimetry to facilitate the translation of research findings into clinical practice. Several systems are available that provide precise delivery…
TGFβ inhibition prior to hypofractionated radiation enhances efficacy in preclinical models
…the efficacy of treatments such as chemotherapy, surgery, and radiotherapy. This study was designed to test the hypothesis that an improved immune environment in the tumor at the time of…
Mild hyperthermia as a localized radiosensitizer for deep-seated tumors: investigation in an orthotopic prostate cancer model in mice.
…research platform. In each case, a dual arc plan was used to deliver 12 Gy to the target in a single fraction. One animal from each cohort was euthanized on…
Xstrahl SARRP features in new Bioluminescence Tomography paper
…with the Xstrahl SARRP. The BLT images are fused with onboard CBCT images for targeting. Validation of the targeting accuracy was completed in phantoms and in vivo. The CBCT/BLT targeting…
Kilovoltage radiotherapy for companion animals: dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams
…300 kV (0–0.4 cm) and 450 kV (0–0.8 cm) X-ray beams were much shorter than that for the 6 MV X-ray beam (1.6 cm), which may result in weaker skin…
Xstrahl in Action: Small field dosimetry for the small animal radiotherapy research platform (SARRP)
…deliver a specific dose to the target will take longer than a broad focal spot, but the beam quality will be better. It is important to choose the electron beam…
Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases
…involved remain to be elucidated. More recent findings, however, indicate the involvement of radiation-sensitive targets like mitotic fibroblasts/myofibroblasts as well as inflammatory cells. Radiation-related molecular mechanisms affecting these target cells…
Easy Non-Surgical Superficial Radiation Therapy was Ideal for My Skin Cancer
…days since I live so close by the office. It was such an easy process of simply seeing your dermatologist. They usually did treatments twice a week which could simply…