A new paper titled “Bioluminescence Tomography – Guided Radiation Therapy for Preclinical Research” has been published in the International Journal of Radiation Oncology. The Xstrahl SARRP system was used for the research conducted in the published paper, the study details how Bioluminescence has enabled researchers to precisely visualize their tumors in vivo. BLI does not give insight to the depth of tumors which is essential for focal irradiation delivery and dose distribution. The study outlines the design and validation of a Bioluminescence Tomography system for targeting orthotopic tumors in vivo with the Xstrahl SARRP. The BLT images are fused with onboard CBCT images for targeting. Validation of the targeting accuracy was completed in phantoms and in vivo. The CBCT/BLT targeting was able to differentiate multiple sources and accurately locate the Center of Mass of light sources. This system has been showed to successfully target orthotopic tumors with the SARRP which are difficult to distinguish with CBCT alone.
Link to full paper – http://www.redjournal.org/article/S0360-3016(15)26787-9/abstract
Article title: Bioluminescence Tomography–Guided Radiation Therapy for Preclinical Research
Authors: Bin Zhang, PhD, Ken Kang-Hsin Wang, PhD, Jingjing Yu, PhD, Sohrab Eslami, PhD, Iulian Iordachita, PhD, Juvenal Reyes, MD, Reem Malek, PhD, Phuoc T. Tran, MD, PhD, Michael S. Patterson, PhD, John W. Wong, PhD