…planning. Their irradiation strategy has been two-fold endorsed. The millimetric ballistic specificity of their mouse models was first validated by measuring gamma-H2AX increase after irradiation. As expected, increased gamma-H2AX staining…
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Xstrahl in Action: Orthovoltage X-rays for Postoperative Treatment of Resected Basal Cell Carcinoma in the Head and Neck
…and report on local control and toxicity of postoperative treatment of residual or recurrent BCCs in the head and neck area after being treated with orthovoltage X-rays. Sixty-six surgically resected…
The Importance of Radiation Dose, Fractionation, and Cellular Responses in Optimizing Immunotherapy
Throughout the last 100 years, numerous milestones in the study and treatment of cancer have been achieved. Discoveries like combination chemotherapy, correlation of smoking and lung cancer, HPV and cervical…
Xstrahl in Action: Radiation dose enhancement in skin therapy with nanoparticle addition
…study “Radiation dose enhancement in skin therapy with nanoparticle addition: A Monte Carlo study on kilovoltage photon and megavoltage electron beams” investigated the dose enhancement due to the incorporation of…
Xstrahl in Action: SARRP Assists in Studying the Role of Genetics in Radiosensitivity of Mice Bladders
…develop RC in response to irradiation treatment, which could impact treatment approach and follow-up recommendations.” The value of SARRP: In this study, researchers assessed the results of pelvic radiation on…
Unique Model Development For Precise Targeting Using SARRP
Radiation induced normal tissue damage and toxicity is sometimes an inevitable side effect when treating tumors with radiation therapy. Despite the technological advancements in imaging, treatment planning, and dose delivery,…
SARRP Used in In Vivo PARP Inhibitor Research
In the recent publication, Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy, researchers examined treatment modalities to aid the development of PARP inhibitors. These compounds target…
Xstrahl in action: New Expansion Protocols Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma
…of therapy is the requirement for high amounts of functional NK cells. The study “A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity…
Xstrahl in Action: A Comprehensive Model for Heat-Induced Radiosensitisation
…widely used in pre-clinical small animal imaging studies (such as those preformed on the Xstrahl SARRP) to assess the progression of diseases such as cancer, aiding in the development of…
Xstrahl in Action: Low dose treatment counteracts and enhances the anti-tumor effect
…tumor blood vessel growth, i.e. angiostatic therapy. Recent findings show that proper scheduling of both treatment modalities allows dose reduction of angiostatic drugs without affecting therapeutic efficacy. In their study…