The XenX irradiator platform has been designed to allow high throughput targeted irradiation studies on cells and small animals. XenX is equipped with a 225 kVp X-ray tube and a 360 degree rotational gantry to allow beam delivery from any angle. Portal imaging allows for a beams eye view of the specimen, and the ability to perform a double exposure technique enables targeting of orthotopic and ectopic tumors with a collimated beam.
An upgrade from a standard, fixed source, single planar X-ray cabinet irradiator. The XenX allows investigators to deliver beams of radiation in a clinically relevant and translatable way. These techniques result in a more 3D conformal dose to the target area, while drastically minimizing normal tissue and surrounding tissue toxicity. With the ability to deliver a beam or radiation from any angle, XenX allows you to investigate and answer questions that were otherwise unattainable with a fixed beam cabinet irradiator.
Unlike any fixed source cabinet irradiator, XenX pairs X-ray imaging with a 360° degree rotational gantry for accurate targeting of an X-ray beam. XenX utilizes a portal imaging camera and X-ray technology to acquire an image of the specimen resulting in visualization and validation of the target. Prior to the development of cone beam-CT imaging, clinical radiation oncology practice utilized an imaging technique called the “double exposure”. Here an open field X-ray image, and collimated X-ray image are overlaid to verify the treatment area. This technique is easily achieved with XenX and is your first step into image guidance.
A fast simple dose calculator based on depth in tissue is a standard feature on XenX. The depth can be measured on the lateral portal image. The treatment time will be calculated based on the measured depth.
XenX enables investigators from various backgrounds to perform clinically relevant research in a preclinical laboratory setting. The ability to mimic clinical radiation practice in an in vivo model allows for investigation of research end points that have not been attainable up until now. Adopting clinical techniques like imaging, target localization, and avoidance of normal tissue toxicity will only drive the field and understanding of radiation effects to the tumor forward.
XENX will greatly improve the accuracy and reproducibility of in vitro experiments. Most radiation research systems have a fixed X-ray source, which can result in beam attenuation and uneven dose distribution to the cell suspension. The XENX’s 360 degree rotating gantry allows investigators to account for this by giving the option of irradiating from above and underneath the flask. This technique ensures a uniform dose to all suspended and adherent cells.
For those experiments that require stacking plates, the stack can be irradiated from top and bottom, or side to side. In this configuration, the dose uniformity is within 6% across a 6cm stack of plates; which vastly increases throughput while maintaining a constant dose.
XENX enables researchers to image and target both ectopic and orthotopic tumors in small animal models in a way that has previously been unattainable. The ability of the gantry to rotate 360°, and bed movement in the X, Y, Z, and Θ direction allows for non-coplanar beam delivery from any angle. With the ability to image and irradiate up to 3 mice (or 1 rat) simultaneously, XENX allows investigators to perform accurate and reproducible experiments in a high throughput manner. Aside from high resolution cone beam CT imaging. XENX also employs portal imaging which provides fluoroscopic X-ray imaging in a ‘beams eye view’. Technological advancements of the system such as the motorized variable collimator and respiratory gating system allow for a more dynamic and conformal dose to the targeted area.
XenX is available with a range of fixed collimators, or a variable collimator. The variable collimator allows the user to simply adjust the X-ray field to irradiate only the target, and minimize dose to other tissue. With a beam size from 0.0mm to 4 cm x 8cm the system is capable of targeting whole organs xenographs or specific orthotropic tumors.
Throughput is accelerated by using the built in X-ray Field light to align the target. Fixed collimators from 5mm give a quick and efficient beam size, with minimal scatter.
The use of collimators and multiple beam arrangements have led to much higher fractionated doses being delivered. Several groups have proved that clinical dose regimes of up 60Gy can be delivered over a 7 week period compared to conventional lead cut-out based experiments.
There have been over 100 articles published with the help of the SARRP and Xenx. For the full list of articles please click here to be directed to our publication resource page.
External: W-148 cm, D-104 cm, H-205 cm
Total Weight Shielded: Cabinet: 2200 kg
Total Weight Unshielded: Cabinet: 360 kg
Treatment distances: 30-38cm or 80cm FSD
Maximum Field Size: 18 cm circle at 35 cm FSD
Tube Voltage: 20-220 kV
Tube Current: 0-25 mA
Maximum Power Output: 3 kW
Mobile Built on wheels for simple transport
Manual Stage Z direction manual movements
Control Interface Operates X-rays
The XenX irradiator platform has been designed to allow high throughput targeted irradiation studies on cells and small animals. Check out the rest of our Life Sciences range.