We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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SPOTLIGHT: High Throughput IGRT on SAARP – A Biotech Perspective
https://vimeo.com/1099450901?share=copy#t=0 In this insightful session, Derrik Germain dives deep into the world of high-throughput image-guided radiotherapy (IGRT) using the SARRP system. He shares his expertise on optimizing workflows, improving throughput, and...
