We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
Superficial radiation therapy treatment provides a non-surgical option for patients with basal cell carcinoma, squamous cell carcinoma, and keloid scarring. In this webcast, Dr. Colin Dicks, Radiation Oncologist from Just Skin in Australia, describes more about the...