We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Radiation Research QA Made Simple — A Step-by-Step Video Guide
Radiation Research QA Made Simple — A Step-by-Step Video Guide to Performing Output Consistency Checks Accurate, reproducible results in radiation research begin with rigorous quality assurance. Required by leading journals and funding agencies, regular QA ensures...
