We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
Download Paper
Low-Dose Radiotherapy (LDRT): How does it work?
Low-dose radiotherapy (LDRT) is a treatment for osteoarthritis (OA) and other degenerative joint conditions, with roots tracing back over a century. Though once widespread, LDRT fell out of favor in some countries due to radiophobia and shifting medical priorities....
