We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Low-Dose Radiotherapy for Osteoarthritis
Xstrahl's Medical Director, Dr. Richard Shaffer, recently spoke for a webinar hosted by Joint Pain Practice. He shares how low-dose radiotherapy can be used for osteoarthritis, and overviews the treatment process, risks, and efficacy. https://youtu.be/ab4iyfhN_L8...