We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
Expanding Patient-Centric Treatment Options for NMSC with Radiation Therapy
Dermatologists are frequently leading the way in the diagnosis and management of non-melanoma skin cancer (NMSC). While Mohs surgery is the standard of care in the treatment of NMSC, the final decision on treatment for the patient should be based on their health, age,...