BACKGROUND/AIMS: Alterations of cytosolic Ca2+-activity ([Ca2+]i) are decisive in the regulation of tumor cell proliferation, migration and survival. Transport processes participating in the regulation of [Ca2+]i include Ca2+ extrusion through K+-independent (NCX)...
Although glucocorticoids (GCs) are a mainstay in the clinical management of asthma, the target cells that mediate their therapeutic effects are unknown. Contrary to our expectation, we found that GC receptor (GR) expression in immune cells was dispensable for...
BACKGROUND AND PURPOSE: To evaluate the impact of ATR inhibition using AZD6738 in combination with radiotherapy on the response of non-small cell lung cancer (NSCLC) tumour models and a murine model of radiation induced fibrosis. MATERIALS AND METHODS: AZD6738 was...
July 3rd, 2017 – It has become a good tradition for Xstrahl Medical to sponsor the Skin Cancer Radiotherapy Study Day at Norfolk and Norwich University Hospital, which this year is taking place on 5 August. The one day skin cancer radiotherapy course is for clinical...
To recommend imaging protocols and establish tolerance levels for microCT image quality assurance (QA) performed on conformal image-guided small animal irradiators. A fully automated QA software SAPA (small animal phantom analyzer) for image analysis of the commercial...
The pain relief effect of the radiation was known after the discovery of the x-ray beams at the end of the 19th century. At the beginning of the 20th century the radiation therapy was used to treat not only benign conditions but also malignant tumours. This has...
Since mid-May, Geislingen clinic has had a radiotherapy system, which allows the patients to save the time they used to spend to get to the one-minute therapy sessions in Göppingen clinic. The Doctor Dr. Hans-Joachim Thiel is pleased: Since mid-May, the modern...
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. New therapeutic concepts in anti-tumor therapy aim to...
The 15th biannual International Wolfsberg Meeting Series met this week, to focusing on molecular radiation biology and oncology in the historic Wolfsberg Castle in Switzerland. Along with the various attendees and sponsors, Xstrahl Medical attended to support the...
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