The mission of most cancer centers, in some shape or form, is to contribute to the prevention and cure of cancer. To accomplish such a mission, a large focus must be placed on research in both the clinical and pre-clinical laboratory setting. In order to yield...
Purpose/Objective To establish a novel preclinical model for stereotactic radiosurgery with combined mouse-like phantom quality assurance in the setting of brain metastases. Material Methods C57B6 mice underwent intracranial injection of B16-F10 melanoma cells....
The SARRP User Spring Symposium event gathers together thought leaders, scholars and operators of Xstrahl Small Animal Radiation Research (SARRP) systems from all over the world.
The development and construction of clinical proton therapy centers has almost become the norm for any major cancer treatment center. Roughly 58 proton centers are currently operating throughout the world, and an estimated 52 (this number could be greater) are currently being built or are planned for construction. With the recent emergence of so many proton centers more so than ever, one would think the use of protons in cancer is a new form of treatment. However, the truth of the matter is it’s basically the opposite.
Background and Purpose: Currently, no readily available mitigators exist for acute abdominal radiation injury. Here, we present an animal model for precise and homogenous limb-sparing abdominal irradiation (LSAIR) to study the radiation-induced gastrointestinal...
Radiation is an important treatment modality for gastrointestinal tumors, but intestinal injury is a common side effect. Here we describe a physiologically relevant model for studying the molecular determinants of radiation-induced intestinal damage and testing novel...
Background: Radiation therapy is a standard established treatment modality for many malignancies, including lymphoma. There is growing evidence that the combination of radiation and immunotherapies can have synergistic immune and clinical effects; however, the...
There are many unknowns in the radiobiology of proton beams and other particle beams. We describe the development and testing of an image-guided low-energy proton system optimized for radiobiological research applications. A 50 MeV proton beam from an existing...
In response to the limitations of computed tomography (CT) and cone-beam CT (CBCT) in irradiation guidance, especially for soft-tissue targets without the use of contrast agents, our group developed a solution that implemented bioluminescence tomography (BLT) as the...
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