In this study, we investigate the use of multifunctional smart radiotherapy biomaterials (SRBs) loaded with immunoadjuvants for boosting the abscopal effect of local radiotherapy (RT). SRBs were designed similar to currently used inert RT biomaterials, incorporating a...
PURPOSE: The aim was to reduce radiation exposure of the lung in experimental models to increase overall survival of mice to study late radiation-induced heart disease. METHODS AND MATERIALS: A new irradiation plan was established on the Small Animal Radiation...
ASTRO Interview with Dr. Eric Ford A few months ago, I received the opportunity to sit down with notable physicist, professor, and experimental radiobiology researcher, Dr. Eric Ford. As one of the masterminds behind the Precision Proton Radiotherapy Platform, which...
Outside of getting excited about playoff hockey and snowboard trips out west, I also find myself enthusiastic about studies/efforts in cancer biology that push the boundaries to further characterize pre-clinical cancer models in a clinical way. The study presented in...
Throughout the last 100 years, numerous milestones in the study and treatment of cancer have been achieved. Discoveries like combination chemotherapy, correlation of smoking and lung cancer, HPV and cervical carcinogenesis, BRCA-1&2 gene inheritance and breast...
BACKGROUND: Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image...
The consequences of low to moderate doses of ionizing radiation (IR), especially for children exposed to CT scans, remains a challenging scientific topic. So far, no proper experimental models are available to better comprehend the consequences of exposure of the...
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an...
Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens usually consisting of a mix of surgery, chemotherapy, radiotherapy, stem cell transplant, immunotherapy and retinoid therapy. However, because...
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