Over 60% of cancer patients worldwide will receive radiotherapy as a part of their overall treatment plan. Recently, stereotactic body radiation therapy (SBRT) has been recognized as a favorable treatment option for those cancer types that remain inoperable. SBRT administers very high doses of radiation in a small number of fractions, and has been shown to achieve 3-year control rates of roughly 90% in stage 1 NSCLC’s.
Research Systems
Immunotherapy and SARRP; a breakthrough investigation using a clinically relevant model to yield clinically relevant data
Pancreatic ductal adenocarcinoma (PDAC) is characteristically radioresistant tumor type with roughly 25% of patients requiring radiotherapy as form of treatment. With poor clinical outcomes (5-year survival of 7%) new and innovative treatments are required to improve patient outcome. Due to the lack of an effective treatment in the clinic for PDAC, translational research yielding clinically relevant results is necessary to develop new and effective treatment.
Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer
Purpose To implement clinical stereotactic body radiation therapy (SBRT) using a small animal radiation research platform (SARRP) in a genetically engineered mouse model of lung cancer. Methods and Materials A murine model of multinodular Kras-driven spontaneous lung...
Tumor-derived CCL2 mediates resistance to radiotherapy in pancreatic ductal adenocarcinoma
Purpose: Local tumor growth is a major cause of morbidity and mortality in nearly 30% of patients with pancreatic ductal adenocarcinoma (PDAC). Radiotherapy (RT) is commonly used for local disease control in PDAC, but efficacy is limited. We studied the impact of...
Xstrahl SARRP features in new Bioluminescence Tomography paper
A new paper titled “Bioluminescence Tomography – Guided Radiation Therapy for Preclinical Research” has been published in the International Journal of Radiation Oncology. The Xstrahl SARRP system was used for the research conducted in the published paper, the study details how Bioluminescence has enabled researchers to precisely visualize their tumors in vivo.
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape.
In preclinical radiation research, it is challenging to localize soft tissue targets based on cone beam computed tomography (CBCT) guidance. As a more effective method to localize soft tissue targets, we developed an online bioluminescence tomography (BLT) system for small-animal radiation research platform (SARRP). We demonstrated BLT-guided radiation therapy and validated targeting accuracy based on a newly developed reconstruction algorithm.
Zhang B, Wang KK, Yu J, Eslami S, Iordachita I, Reyes J, Malek R, Tran PT, Patterson MS, Wong JW.
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Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research
PURPOSE: In preclinical radiation research, it is challenging to localize soft tissue targets based on cone beam computed tomography (CBCT) guidance. As a more effective method to localize soft tissue targets, we developed an online bioluminescence tomography (BLT)...
Proposal for a Simple and Efficient Monthly Quality Management Program Assessing the Consistency of Robotic Image-Guided Small Animal Radiation Systems
Modern pre-clinical radiation therapy (RT) research requires high precision and accurate dosimetry to facilitate the translation of research findings into clinical practice. Several systems are available that provide precise delivery and on-board imaging capabilities,...
Comprehensive quality assurance phantom for the small animal radiation research platform (SARRP)
PURPOSE: To develop and test the suitability and performance of a comprehensive quality assurance (QA) phantom for the Small Animal Radiation Research Platform (SARRP). METHODS AND MATERIALS: A QA phantom was developed for carrying out daily, monthly and annual QA...