BACKGROUND: Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image...
The consequences of low to moderate doses of ionizing radiation (IR), especially for children exposed to CT scans, remains a challenging scientific topic. So far, no proper experimental models are available to better comprehend the consequences of exposure of the...
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an...
Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens usually consisting of a mix of surgery, chemotherapy, radiotherapy, stem cell transplant, immunotherapy and retinoid therapy. However, because...
At the 2017 Annual Meeting of the American Society for Radiation Oncology (ASTRO) researchers announced the development of an efficient and reproducible method to deliver craniospinal irradiation to patient-derived xenograft in mouse models. Despite aggressive...
Patients with glioblastoma have poor outcomes due to local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficiency of DNA repair cells, such as RAD51, are able to survive DNA damage from radiotherapy and...
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has only marginally improved. New therapeutic concepts in anti-tumor therapy aim...
Radiation induced normal tissue damage and toxicity is sometimes an inevitable side effect when treating tumors with radiation therapy. Despite the technological advancements in imaging, treatment planning, and dose delivery, radiation exposure to organs and tissues...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitising agents...
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