DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and its ligand PD-L1 has been...
Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor...
PURPOSE: The goal of this work was to develop and test a cylindrical tissue-equivalent quality assurance (QA) phantom for micro computed tomography (microCT) image-guided small animal irradiators that overcomes deficiencies of existing phantoms due to its mouse-like...
April 24th, 2019 New 150kV superficial treatment system spotlighted on Xstrahl booth (No. 3420) at ESTRO show in Milan, Italy, April 26th-29th Xstrahl Medical, global leader in superficial radiotherapy devices to treat non-melanoma skin cancer and dermatological...
The extent of tumor oxygenation is an important factor contributing to the efficacy of radiation therapy. Several preclinical studies have shown benefit of combining radiation therapy with drugs that inhibit tumor blood vessel growth, i.e. angiostatic therapy. Recent...
Current treatment methods for arteriovenous malformation (AVM) are surgery and radiosurgery. However, complete occlusion post radiosurgery is achieved within 3 years, while patient remain at risk of haemorrhage. Therefore is important to develop a new molecular...
The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. In a previous paper by Nile DL, Rae...
The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. In their paper “Importance of dosimetry...
Knee bone marrow edema is often diagnosed with the help of MRI as a consequence of trauma, overload, surgery, arthrosis or osteonecrosis. One of its most common reasons is cruciate ligament rupture surgery. The edema pathogenesis is not known for sure. The bone marrow...
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