PURPOSE: To show radiation dose-response relationships for recurrence of keloid and pterygium after radiotherapy following surgery. METHODS AND MATERIALS: Using PubMed, we performed a retrospective review of articles reporting incidences and/or dose-response...
Despite the emphasis on megavoltage radiation therapy, kV units are still being acquired and used in clinical radiation therapy for superficial lesions and specialized treatment techniques. The dosimetry of kV X-ray beams is tricky and subject to increased...
We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The Small Animal Radiation Research Platform (SARRP) is a portable system for...
The American Association of Physicists in Medicine (AAPM) formed a Task Group under the Unconventional Brachytherapy Working Group of the Brachytherapy Subcommittee and the Radiation Safety Subcommittee of the Therapy Physics Committee (TPC). This Task Group, TG-152,...
N C Northrup 1 , S M Etue, D M Ruslander, K M Rassnick, D L Hutto, A Bengtson, W Rand, A S Moore PMID: 11380025 DOI: 10.1892/0891-6640(2001)015<0183:rsoort>2.3.co;2 Abstract Megavoltage radiation therapy currently is the standard of care for dogs with nasal...
Preclinical research using well characterized small animal models has provided tremendous benefits to medical research, enabling low cost, large scale trials with high statistical significance of observed effects. The goal of the Small Animal Radiation Research...
BACKGROUND: We explore the use of a clinical orthovoltage X-ray treatment unit as a small-animal radiation therapy system in a tumoral model of cervical cancer. METHOD: Nude mice were subcutaneously inoculated with 5 × 106 HeLa cells in both lower limbs. When tumor...
BACKGROUND: A lot of retrospective data concerning the effect of radiotherapy on the painful heel spur (plantar fasciitis) is available in the literature. Nevertheless, a randomized proof of this effect is still missing. Thus, the GCGBD (German cooperative group on...
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