The extent of tumor oxygenation is an important factor contributing to the efficacy of radiation therapy. Several preclinical studies have shown benefit of combining radiation therapy with drugs that inhibit tumor blood vessel growth, i.e. angiostatic therapy. Recent...
Current treatment methods for arteriovenous malformation (AVM) are surgery and radiosurgery. However, complete occlusion post radiosurgery is achieved within 3 years, while patient remain at risk of haemorrhage. Therefore is important to develop a new molecular...
Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8+...
The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. In a previous paper by Nile DL, Rae...
Low dose radiation therapy is the typical treatment for elderly patients aged ≥70 years, for painful benign skeletal disorders such as calcaneodynia, achillodynia, painful gonarthrosis, and painful bursitis trochanterica. However the short- and long-term efficacy has...
The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. In their paper “Importance of dosimetry...
Knee bone marrow edema is often diagnosed with the help of MRI as a consequence of trauma, overload, surgery, arthrosis or osteonecrosis. One of its most common reasons is cruciate ligament rupture surgery. The edema pathogenesis is not known for sure. The bone marrow...
Despite a major paradigm shift in radiotherapy planning and delivery over the past three decades with continuing refinements, radiation-induced lung damage (RILD) remains a major dose limiting toxicity in patients receiving thoracic irradiations. Our current...
Although small animal image-guided radiotherapy (SA-IGRT) systems are used increasingly in preclinical research, tools for performing routine quality assurance have not been optimized and are not readily available. Robust, efficient, and reliable quality assurance...
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