Dose measurements in pre-clinical and radiobiology studies are frequently inadequate, thus undermining the reliability and reproducibility of the published findings.
Nicole Grosse, Andrea O Fontana, Eugen B. Hug, Antony Lomax, Adolf Coray, Marc Augsburger, Harald Paganetti, Alessandro A Sartori, and Martin Pruschy
Download Paper
Resources
Dose Painting with a Variable Collimator with the Small Animal Radiation Research Platform (SARRP).
The goal of radiation treatment is to irradiate cancer cells (i.e., a target region) without destroying adjacent healthy tissue. Thus, it is advantageous to form the beam so that it best approximates the target, thereby reducing the amount of dose absorbed in critical regions outside the target area. While multi-leaf collimators are common in human clinical systems, small animal radiotherapy systems are typically limited to a set of fixed-size collimators. For these systems, dose painting can be used for conformal dose delivery, but is significantly slower than a multi-leaf collimator. As a compromise solution, a variable rectangular collimator has been developed for the Small Animal Radiation Research Platform (SARRP). This enables more efficient dose painting via the decomposition of a 2D target region into a minimum number of rectangles of variable size, which is the topic of this paper. The proposed method consists of several distinct steps and was implemented on the SARRP Treatment Planning System (TPS).
Cho N., Wong J., Kazanzides P.
Download Paper
The Importance of Dosimetry Standardization in Radiobiology
DTo investigate the impact of the 2 major DNA repair machineries on cellular survival in response to irradiation with the 2 types of ionizing radiation.
Anna Subiel, Giuseppe Schettino et al
Download Paper
Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model
BACKGROUND: The inability of structural MRI to accurately measure tumor response to therapy complicates care management for patients with gliomas. The purpose of this study was to assess the potential of several noninvasive functional and molecular MRI biomarkers for...
Theranostic gold nanoparticles modified for durable systemic circulation effectively and safely enhance the radiation therapy of human sarcoma cells and tumors
Radiation therapy (RT) is an integral component of the treatment of many sarcomas and relies on accurate targeting of tumor tissue. Despite conventional treatment planning and RT, local failure rates of 10% to 28% at 5 years have been reported for locally advanced,...
Evidence-based treatment for low-risk basal cell carcinoma
Basal-cell carcinoma is the most common cancer worldwide, with more than 2 million lesions treated in the USA in 2006.1,2 In the UK, many basal-cell carcinomas are not registered, which greatly underestimates the numbers of individuals affected.3 Incidence is...
Effect of field size and length of plantar spur on treatment outcome in radiation therapy of plantar fasciitis: the bigger the better?
PURPOSE: Radiation therapy is well established in the treatment of painful plantar fasciitis or heel spur. A retrospective analysis was conducted to investigate the effect of field definition on treatment outcome and to determine the impact of factors potentially...
Hematopoietic Stem and Progenitor Cell Migration After Hypofractionated Radiation Therapy in a Murine Model.
To characterize the recruitment of bone marrow (BM)-derived hematopoietic stem and progenitor cells (HSPCs) within tumor microenvironment after radiation therapy (RT) in a murine, heterotopic tumor model.
Jonathan Kane, Sarah A. Krueger, Joshua T. Dilworth, John T. Torma, George D. Wilson, Brian Marples, Gerard J. Madlambayan
Download Paper
Functional interrogation of adult hypothalamic neurogenesis with focal radiological inhibition
The functional characterization of adult-born neurons remains a significant challenge. Approaches to inhibit adult neurogenesis via invasive viral delivery or transgenic animals have potential confounds that make interpretation of results from these studies difficult....