Life Sciences
RS225
  • RS225 RS225
  • RS225 RS225

RS225

Meeting the needs of medical and biological research, the RS225 is a self-contained cabinet incorporating the irradiation chamber and system electronics in one enclosure. The software interface allows for multiple user logins, while X-Ray exposures can be programmed and executed automatically. In addition to removing the health and safety burden associated with the use of radioactive sources, the Xstrahl RS225 provides a safer, simpler and less costly alternative to radioisotope irradiators for radiation exposure studies.

 

The RS225 X-Ray research irradiator cabinet consists of:

•  Lead shielded irradiation chamber

•  Movable operator control panel with an intuitive touch screen interface

•  Beam hardening filters, to tailor the maximum depth of an X-Rays to suit the research

•  Unique motorised vertical movement access door, resulting in a smaller footprint and safe, easy access to specimens

Contact us
Research Applications
  • Bystander effects
  • Radiosensitivity of normal tissue
  • Preclinical studies
  • Radiosensitizers
  • In-vivo irradiation
  • In-vitro irradiation
  • Oncology
  • Radiobiology tumour micro-environment
  • DNA repair
Device Specification

External: W-110.5cm, D-96cm, H-201cm
Irradiation Chamber: W-57 cm, D-60 cm, H-65 cm
Total Weight: Cabinet: 1,100 kg
Irradiation Table: Manual adjustment of the specimen shelf 20cm to 70cm FSD
Maximum Field Size: 43.5cm circle at 70cm FSD
Tube Voltage: Up to 220 kV
Tube Current: 1.0mA to 30mA
Maximum Power Output: 3 kW (broad focus for designated stability)

 

Optional Items

  • Additional collimators to vary irradiated size area
  • Alignment laser system for easy specimen setup
  • CCTV (camera) for internal observation of the chamber during operation/exposure
  • Hypoxia gas control chamber for in-vitro studies
  • Independent dose measurement systems
  • Touch screen controlled specimen turntable option


Bespoke Commissioning
Bespoke commissioning of the cabinet based on your research needs in order to provide the most accurate dosimetry data for your research.

Publications
  1. Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM (2011). Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death. The Journal of Immunology, Vol. 187 (9). Germany

  2. Toulany M, Schickfluß T, Eicheler W, Kehlbach R, Schittek B, Rodemann P (2011). Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation. Breast Cancer Research, Vol 13 (2) . Germany

  3. Sohn D, Budach W, Jänicke R (2011). Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21. Cell Death and Differentiation, Vol 18 (10). Germany

  4. Kasten-Pisula U, Saker J, Eicheler W, Krause M, Yaromina A, Meyer-Staeckling S, Scherkl B, Kriegs M, Brandt B, Grénman R, Petersen C, Baumann M, Dikomey E (2011). Cellular and tumor radiosensitivity is correlated to epidermal growth factor receptor protein expression level in tumors without EGFR amplification. International Journal of Radiation Oncology, Biology, Physics. Vol 80 (4). Germany

  5. Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG (2010). Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma. Radiation Research, Vol 174 (6). Ireland

  6. Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA (2010). p53 is a direct transcriptional target of MYCN in neuroblastoma. Cancer Research, Vol 70 (4). United Kingdom.

  7. Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S, Mukhopadhyay A, Los G, Hostomsky Z, Plummer ER, Edmondson RJ, Curtin NJ (2010). Therapeutic potential of poly (ADP-ribose) polymerase Inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. Journal of the National Cancer Institute, Vol 103 (4). United Kingdom

  8. Martin L, Marples B, Coffey M, Lawler M, Hollywood D, Marignol L (2009). Recognition of 06MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. Radiation Research, Vol 172 (4). Ireland

  9. Welke K, Schneider JM (2009). Inbreeding avoidance through cryptic female choice in the cannibalistic orb-web spider Argiope lobata. Behavioral Ecology, Vol 20 (5). Germany

  10. Schneider JM, Lesmono K (2009). Courtship raises male fertilization success through post-mating sexual selection in a spider. Proceedings in Biological Sciences. Germany

  11. Nessler SH, Uhl G, Schneider JM (2009). Sexual cannibalism facilitates genital damage in Argiope lobata (Araneae: Araneidae). Behavioral Ecoloogy and Sociobiology, Vol 63 (3). Germany

  12. Marignol L, Foley R, Southgate TD, Coffey M, Hollywood D, Lawler M (2009). Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro. The Journal of Gene Medicine, Vol 11 (2). Ireland.

  13. Wanner G, Mayer C, Kehlbach R, Rodemann HP, Dittmann K (2008). Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiotherapy & Oncology, Vol 86 (3). Germany

  14. Dittman K, Mayer C, Kehlbach R, Rodemann HP (2008). Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Molecular Cancer, Vol 7 (69). Germany

  15. Prevo R, Deutsch E, Sampson O, Diplexcito J, Cenjel K, Harper J, O'Neill P, McKenna WG, Patel S, Bernhard EJ (2008). Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine Inhibitor PI-103 enhances tumor radiosensitivity. Cancer Research, Vol 68. United Kingdom

  16. Dittmann K, Mayer C, Wanner G, Kehlbach R, Rodemann HP (2007). The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor-and-DNA-dependent kinase phosphorylation. Radiotherapy & Oncology, Vol 84 (3). Germany

  17. Toulany M, Baumann M, Rodemann HP (2007). Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Molecular Cancer Research, Vol 5 (8). Germany

  18. Bell E, Premkumar R, Carr J, Lu X, Lovat PE, Kees UR, Lunec J, Tweddle DA (2006). The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage. Cell Cycle, Vol 5 (22). United Kingdom

  19. Dittmann K, Mayer C, Rodemann HP (2005). Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiotherapy & Oncology, Vol 76 (2). Germany.
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