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X-Rays Minibeam Radiation Therapy at a Conventional Irradiator: Pilot Evaluation in F98-Glioma Bearing Rats and Dose Calculations in a Human Phantom

Publication: X-Rays Minibeam Radiation Therapy at a Conventional Irradiator: Pilot Evaluation in F98-Glioma Bearing Rats and Dose Calculations in a Human Phantom

Authors: Sotiropoulos, Marios Brisebard, Elise Le Dudal, Marine Jouvion, Gregory Juchaux, Marjorie Crépin, Delphine Sebrie, Catherine Jourdain, Laurene Labiod, Dalila Lamirault, Charlotte Pouzoulet, Frederic Prezado, Yolanda

Abstract

Minibeam radiation therapy (MBRT) is a type of spatial fractionated radiotherapy that uses submillimetric beams. This work reports on a pilot study on normal tissue response and the increase of the lifespan of glioma-bearing rats when irradiated with a tabletop x-ray system. Our results show a significant widening of the therapeutic window for brain tumours treated with MBRT: an important proportion of long-term survivals (60%) coupled with a significant reduction of toxicity when compared with conventional (broad beam) irradiations. In addition, the clinical translation of the minibeam treatment at a conventional irradiator is evaluated through a possible human head treatment plan.

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