…Treg in the TME, in the paper “Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment” Muroyama Y, Nirschl TR, Kochel CM, et al, selectively irradiated implanted…
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Xstrahl in Action: Effect of X-ray minibeam radiation therapy on clonogenic survival of glioma cells
…of clonogenic survival, whereas in U87 cells there was still a slightly increased survival with MB compared to BB 19 Gy treatment. The results suggest also an impairment of DNA…
Xstrahl In Action: Quantitative bioluminescence tomography using spectral derivative data
…widely used in pre-clinical small animal imaging studies (such as those preformed on the Xstrahl SARRP) to assess the progression of diseases such as cancer, aiding in the development of…
Xstrahl in Action: ATM inhibitors radiosensitize and improves survival of preclinical brain tumor models
…models, AZD1390 dosed in combination with daily fractions of IR (whole-brain or stereotactic radiotherapy) using the Xstrahl SARRP significantly induced tumor regressions and increased animal survival compared to IR treatment…
Xstrahl in Action: SARRP used in characterization of plastic scintillating detector
…compute detailed energy spectra at locations of dosimetry, and validated scintillator measurement with MC simulations. Mass energy-absorption coefficients from the National Institute of Standards and Technology (NIST) tables convolved with…
Xstrahl in action: Behavioural Effects of Focal Irradiation in a Juvenile Murine Model
…lack of response of some brain tumours to these agents, radiation therapy is still used to treat many childhood cancers with CNS involvement. In their study “Behavioural Effects of Focal…
Xstrahl in Action: Behavioral Effects of Focal Irradiation in a Juvenile Murine Model
…lack of response of some brain tumours to these agents, radiation therapy is still used to treat many childhood cancers with CNS involvement. In their study “Behavioural Effects of Focal…
Xstrahl in Action: SARRP Used in T-Cell Immunity Study
…study’s results demonstrate that mice that lacking the autophagy genes Atg5, Atg14, orAtg16L1 “display a dramatic impairment in the growth of syngeneic tumors.” Equally important is the finding that the…
SARRP used in Combination Therapy Tumor Suppression
The below graphic displays highlights from the study, “Synergistic Anticancer Activity of N-Hydroxy-7-(2-Naphthylthio Heptanomide, Sorafenib, and Radiation Therapy in Patient-Derived Anaplastic Thyroid Cancer Models” by HJ Yun, HJ Kim, J…
Xstrahl in Action: Priming the Abscopal Effect Using Multifunctional Smart Radiotherapy Biomaterials
…loaded with CD40 mAbs and image-guided radiotherapy. Results also suggest that the use of polymeric SRBs with CD40 mAbs without radiotherapy could generate an immune response, consist*]}*ent with previous studies…