We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
In this tech talk, Dr. Merle Reinhart talks about switching cabinet irradiators, particularly between x-rays and γ-rays. See more about the study she mentioned here. You can also view the recording of a webcast we recently hosted with Dr. Chandan Guha and Brett Bell...