We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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X-rays vs γ-rays in Radiation Research: Tech Talk
In this tech talk, Dr. Merle Reinhart talks about switching cabinet irradiators, particularly between x-rays and γ-rays. See more about the study she mentioned here. You can also view the recording of a webcast we recently hosted with Dr. Chandan Guha and Brett Bell...
