In their paper “Effect of X-ray minibeam radiation therapy on clonogenic survival of glioma cells.” Guardiola C, Prezado Y, Roulin C, Bergs JWJ report on the first in vitro study performed in an X-ray Small Animal Radiation Research Platform (SARRP) modified for...
Radiation exposure is known to cause accelerated aging and damage to the ovary, but the contribution of indirect versus direct effects is not well understood. In their paper “Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and the fastest growing malignancy in the United States. With a 5-year survival rate below 12%, effective therapies for HCC are needed. Current treatments for HCC include microwave...
DNA-damaging chemotherapy and radiation therapy are integrated into the treatment paradigm of the majority of cancer patients. Recently, immunotherapy that targets the immunosuppressive interaction between programmed death 1 (PD-1) and its ligand PD-L1 has been...
Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor...
The extent of tumor oxygenation is an important factor contributing to the efficacy of radiation therapy. Several preclinical studies have shown benefit of combining radiation therapy with drugs that inhibit tumor blood vessel growth, i.e. angiostatic therapy. Recent...
Current treatment methods for arteriovenous malformation (AVM) are surgery and radiosurgery. However, complete occlusion post radiosurgery is achieved within 3 years, while patient remain at risk of haemorrhage. Therefore is important to develop a new molecular...
Low dose radiation therapy is the typical treatment for elderly patients aged ≥70 years, for painful benign skeletal disorders such as calcaneodynia, achillodynia, painful gonarthrosis, and painful bursitis trochanterica. However the short- and long-term efficacy has...
The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. In their paper “Importance of dosimetry...
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