Research Reviews

Outside of getting excited about playoff hockey and snowboard trips out west, I also find myself enthusiastic about studies/efforts in cancer biology that push the boundaries to further characterize pre-clinical cancer models in a clinical way. The study presented in...

Throughout the last 100 years, numerous milestones in the study and treatment of cancer have been achieved. Discoveries like combination chemotherapy, correlation of smoking and lung cancer, HPV and cervical carcinogenesis, BRCA-1&2 gene inheritance and breast...

The consequences of low to moderate doses of ionizing radiation (IR), especially for children exposed to CT scans, remains a challenging scientific topic. So far, no proper experimental models are available to better comprehend the consequences of exposure of the...

Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens usually consisting of a mix of surgery, chemotherapy, radiotherapy, stem cell transplant, immunotherapy and retinoid therapy. However, because...

At the 2017 Annual Meeting of the American Society for Radiation Oncology (ASTRO) researchers announced the development of an efficient and reproducible method to deliver craniospinal irradiation to patient-derived xenograft in mouse models. Despite aggressive...

Patients with glioblastoma have poor outcomes due to local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficiency of DNA repair cells, such as RAD51, are able to survive DNA damage from radiotherapy and...

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has only marginally improved. New therapeutic concepts in anti-tumor therapy aim...

Radiation induced normal tissue damage and toxicity is sometimes an inevitable side effect when treating tumors with radiation therapy. Despite the technological advancements in imaging, treatment planning, and dose delivery, radiation exposure to organs and tissues...