Telomere dysfunction promotes genomic instability and carcinogenesis via inappropriate end-to-end chromosomal rearrangements, or telomere fusions. Previous work indicates that the DNA Damage Response (DDR) factor 53BP1 promotes the fusion of telomeres rendered...
High-dose rate electronic brachytherapy (EBT) using surface applicators allows for convenient hypofractionated treatment of non-melanoma skin cancer (NMSC). However, EBT delivers a higher surface dose as compared to commonly used superficial x-ray or electron...
Treatment of non-melanoma skin cancers (NMSC) in cosmetically sensitive locations can be challenging. Methods of treatment include different modalities of RT (orthovoltage x-rays, electron-beam RT, high-dose rate [HDR] brachytherapy) and surgical excision, all of...
Surgery is the mainstay of treatment for non-melanoma skin cancers (NMSC) unless location or comorbidities mandate noninvasive modalities like radiation. Electrons are commonly used worldwide to treat skin cancers; however, there has been a recent increase in use of...
To report a single-institutional experience with the use of orthovoltage radiation for head and neck non-melanoma cutaneous skin cancer (basal cell carcinoma - BCC, squamous cell carcinoma - SCC, and non-invasive squamous cell carcinoma - SCC in situ) and to compare...
Skin cancer of the head and neck comprise a heterogeneous mix of tumors with differing treatment response and outcomes depending upon histology. We present a large retrospective analysis of these tumors treated in a single institution over a 21-year period. We present...
PURPOSE: Nonmelanoma skin cancer (NMSC) is the commonest cancer in humans. NMSC treatment currently includes surgery, radiation therapy, and topical approaches. The objective was to analyze and compare the outcomes, toxicity, and cosmesis of NMSC treated by two...
The immune infiltrate in colorectal cancer has been correlated with outcome, such that individuals with higher infiltrations of T cells have increased survival independent of the disease stage. For patients with lower immune infiltrates, overall survival is limited....
PURPOSE: This dissertation focuses on establishment of pre-clinical methods facilitating the use of PET imaging for selective sub-volume dose escalation. Specifically the problems addressed are 1.) The difficulties associated with comparing multiple PET images, 2.)...
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