Inhibition of ataxia-telangiectasia mutated (ATM) during radiotherapy of glioblastoma multiforme (GBM) may improve tumor control by short-circuiting the response to radiation-induced DNA damage. A major impediment for clinical implementation is that current inhibitors...
In recent years, small animal image-guided irradiators have been widely utilized in preclinical studies involving rodent models. However, the dosimetry commissioning of such equipment involving kilovoltage small-field dosimetry has not received as much interest as the...
BACKGROUND: Recently, imaging and high-precision irradiation devices for preclinical tumor models have been developed. Image-guided radiation therapy (IGRT) including innovative treatment planning techniques comparable to patient treatment can be achieved in a...
Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor...
Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. The Xstrahl small animal radiation research platform (SARRP) enables state-of-the-art...
For the last 12 years the CIX3 irradiator cabinet has been a stable of cancer research centres around the world. With demand high, Xstrahl spent 2 years developing a new generation of the system, with reduced footprint, safer controls, larger irradiation chamber and...
Xstrahl announced today the opening of a new office and facility in central Germany to help support its current European install base, and work with local governments and facilities to help ensure radiotherapy treatment is available to everyone who needs it. “As...
The aim of this study was to investigate a single crystal diamond detector, the microDiamond detector from PTW (PTW-Freiburg, Freiburg, Germany), concerning the particular requirements in the set-up and energy range used in small animal radiotherapy (RT) research...
Purpose The precise dosimetric and geometric characteristics of small animal irradiators are essential to achieving reproducible dose delivery, especially in cases where image‐guidance is utilized. Currently, radiochromic film is the established measurement tool used...
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