PURPOSE: The Small Animal Radiation Research Platform (SARRP) has been developed for conformal microirradiation with on-board cone beam CT (CBCT) guidance. The graphics processing unit (GPU)-accelerated Superposition-Convolution (SC) method for dose computation has...
Chemotherapy has been successfully used to reduce radiation dose and volume for most pediatric patients. However, because of the failure of chemotherapeutic agents to cross the blood-brain barrier and the lack of response of some brain tumors to these agents,...
Accidental high-dose radiation exposure can result in mortality or severe morbidity through acute radiation syndrome (ARS). The early risk of death from ARS can be attributed mainly to radiation-induced gastrointestinal syndrome (RIGS). Currently, there are no readily...
In this study, we investigate the use of multifunctional smart radiotherapy biomaterials (SRBs) loaded with immunoadjuvants for boosting the abscopal effect of local radiotherapy (RT). SRBs were designed similar to currently used inert RT biomaterials, incorporating a...
PURPOSE: The aim was to reduce radiation exposure of the lung in experimental models to increase overall survival of mice to study late radiation-induced heart disease. METHODS AND MATERIALS: A new irradiation plan was established on the Small Animal Radiation...
ASTRO Interview with Dr. Eric Ford A few months ago, I received the opportunity to sit down with notable physicist, professor, and experimental radiobiology researcher, Dr. Eric Ford. As one of the masterminds behind the Precision Proton Radiotherapy Platform, which...
Chemotherapy and Radiotherapy utilize DNA-PK and PARP inhibitors to sensitize cancer cells, however these inhibitors have so far only been limited to homologous recombination repair deficient tumors, exploiting synthetic lethality. In the study “Sensitizing ewing...
Outside of getting excited about playoff hockey and snowboard trips out west, I also find myself enthusiastic about studies/efforts in cancer biology that push the boundaries to further characterize pre-clinical cancer models in a clinical way. The study presented in...
Throughout the last 100 years, numerous milestones in the study and treatment of cancer have been achieved. Discoveries like combination chemotherapy, correlation of smoking and lung cancer, HPV and cervical carcinogenesis, BRCA-1&2 gene inheritance and breast...
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