Binding of the apolipoprotein E (ApoE)-containing lipoprotein complex to the low-density lipoprotein receptor (LDLR) is essential for cholesterol and lipid homeostasis. Inherited abnormalities in ApoE or LDLR function result in early onset cardiovascular disease and...
In their study “Dosimetric characterization of a single crystal diamond detector in X-ray beams for preclinical research” Severin Kampfer, Nathan Cho Stephanie E. Combs, Jan J.Wilkens, investigated a single crystal diamond detector, the microDiamond detector from PTW,...
The Xstrahl Small Animal Radiation Research Platform (SARRP) has been developed for conformal micro irradiation with on-board cone beam CT guidance. The graphics processing unit (GPU)-accelerated Superposition-Convolution (SC) method for dose computation has been...
OBJECTIVE The mechanical and geometric accuracy of small animal image‐guided radiotherapy (SA‐IGRT) systems is critical and is affected by a number of system‐related factors. Because of the small dimensions involved in preclinical radiotherapy research, such factors...
The precise dosimetric and geometric characteristics of small animal irradiators are essential to achieving reproducible dose delivery, especially in cases where image-guidance is utilized. Currently, radiochromic film is the established measurement tool used to...
Chemotherapy has been successfully used to reduce radiation dose and volume for most paediatric patients. However, because of the failure of chemotherapeutic agents to cross the blood-brain barrier and the lack of response of some brain tumours to these agents,...
OBJECTIVES: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response. MATERIALS AND METHODS: Early radiation...
PURPOSE: The goal of this work was to design a realistic mouse phantom as a useful tool for accurate dosimetry in radiobiology experiments. METHODS: A subcutaneous tumor-bearing mouse was scanned in a microCT scanner, its organs manually segmented and contoured. The...
Bioluminescence imaging (BLI) is a non-contact, optical imaging technique based on measurement of emitted light due to an internal source, which is often directly related to cellular activity. It is widely used in pre-clinical small animal imaging studies (such as...
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