Recently I was asked a question by a colleague, “what is defined by image guided micro-irradiation?” I started to give my normal description along the lines of the process involving imaging, identifying the target in space, being able to target a beam of radiation to...
Dr Wong is the co-inventor of SARRP, The small animal radiation research platform commercialised by Xstrahl and now the premier tool used by radiation biologists, research oncologists and medical physicists in the pursuit of eradicating cancer. Dr. Wong is presently...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitising agents...
BACKGROUND AND PURPOSE: High-precision radiotherapy (RT) requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. The purpose of this study is to establish a pancreatic...
PURPOSE: Despite recent advances in the treatment of metastatic prostate cancer, survival rates are low and treatment options are limited to chemotherapy and hormonal therapy. Although ionizing radiation is used to treat localized and metastatic prostate cancer, the...
Purpose To assess the impact of hypoxia exposure on cellular radiation sensitivity and survival of tumor cells with diverse intrinsic radiation sensitivity under normoxic conditions. Materials and methods Three squamous cell carcinoma (SCC) cell lines, with pronounced...
Despite both clinical and pre-clinical technological advancements, a lack of effective treatment for patients with primary brain tumors and those originating from metastasis remains. With the 5-year survival rate of patients experiencing primary glioblastoma...
The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with...
BACKGROUND/AIMS: Alterations of cytosolic Ca2+-activity ([Ca2+]i) are decisive in the regulation of tumor cell proliferation, migration and survival. Transport processes participating in the regulation of [Ca2+]i include Ca2+ extrusion through K+-independent (NCX)...
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