Patients with glioblastoma have poor outcomes due to local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficiency of DNA repair cells, such as RAD51, are able to survive DNA damage from radiotherapy and...
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has only marginally improved. New therapeutic concepts in anti-tumor therapy aim...
Radiation induced normal tissue damage and toxicity is sometimes an inevitable side effect when treating tumors with radiation therapy. Despite the technological advancements in imaging, treatment planning, and dose delivery, radiation exposure to organs and tissues...
In the present study, we address the important issue of whether B-cells protected from irradiation-induced cell death, may survive with elevated levels of DNA damage. If so, such cells would be at higher risk of gaining mutations and undergoing malignant...
Recently I was asked a question by a colleague, “what is defined by image guided micro-irradiation?” I started to give my normal description along the lines of the process involving imaging, identifying the target in space, being able to target a beam of radiation to...
Dr Wong is the co-inventor of SARRP, The small animal radiation research platform commercialised by Xstrahl and now the premier tool used by radiation biologists, research oncologists and medical physicists in the pursuit of eradicating cancer. Dr. Wong is presently...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitising agents...
BACKGROUND AND PURPOSE: High-precision radiotherapy (RT) requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. The purpose of this study is to establish a pancreatic...
PURPOSE: Despite recent advances in the treatment of metastatic prostate cancer, survival rates are low and treatment options are limited to chemotherapy and hormonal therapy. Although ionizing radiation is used to treat localized and metastatic prostate cancer, the...
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