OBJECTIVES: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response. MATERIALS AND METHODS: Early radiation...
PURPOSE: The goal of this work was to design a realistic mouse phantom as a useful tool for accurate dosimetry in radiobiology experiments. METHODS: A subcutaneous tumor-bearing mouse was scanned in a microCT scanner, its organs manually segmented and contoured. The...
Bioluminescence imaging (BLI) is a non-contact, optical imaging technique based on measurement of emitted light due to an internal source, which is often directly related to cellular activity. It is widely used in pre-clinical small animal imaging studies (such as...
ABSTRACT: Evaluation of the consequences of low to moderate doses of ionizing radiation (IR) remains a societal challenge, especially for children exposed to CT scans. Appropriate experimental models are needed to improve scientific understanding of how exposure of...
PURPOSE: To characterize a small plastic scintillator developed for high resolution, real-time dosimetry of therapy and imaging x-ray beams delivered by an image-guided small animal irradiator. MATERIALS AND METHODS: A 1 mm diameter, 1 mm long polystyrene BCF-60...
PURPOSE: Meningiomas are a frequent tumor of the central nervous system. Although mostly benign, approximately 5% present as atypical or malignant tumors. Treatments for atypical meningiomas include gross total resection and radiotherapy, but about 33% of patients...
OBJECTIVE: Modern image-guided small animal irradiators like the Xstrahl Small Animal Radiation Research Platform (SARRP) are designed with ultrathin 0.15 mm Cu filters, which compared with more heavily filtrated traditional cabinet-style biological irradiators,...
PURPOSE: To evaluate the acute changes in leukocyte populations after focal irradiation and to assess the role of Interleukin-6 (IL6) in acute and late radiation injury. METHODS AND MATERIALS: Mice were surgically implanted with a radiopaque marker on the surface of...
OBJECTIVES: Small animal radiotherapy research platforms such as XStrahl's SARRP enable more precise irradiation of tumours and normal tissues in preclinical models of cancer. Using an orthotopic G7 glioblastoma (GBM) xenograft model we studied the impact of four...
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