The mission of most cancer centers, in some shape or form, is to contribute to the prevention and cure of cancer. To accomplish such a mission, a large focus must be placed on research in both the clinical and pre-clinical laboratory setting. In order to yield...
PURPOSE/OBJECTIVES: Radiation-induced erectile-dysfunction (RiED) is one of the most common side effects of radiation therapy (RT) and significantly reduces the quality of life (QoL) of cancer patients. Approximately 50% of prostate cancer patients experience RiED...
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12-18 Gy in...
Dupuytren's contracture is incredibly common, with rates in England of 20% of the population over the age of 65 having the disease. Causing a debilitating curling of fingers and toes, the most common treatment is surgery, causing long term and painful recovery....
Purpose/Objective To establish a novel preclinical model for stereotactic radiosurgery with combined mouse-like phantom quality assurance in the setting of brain metastases. Material Methods C57B6 mice underwent intracranial injection of B16-F10 melanoma cells....
The SARRP User Spring Symposium event gathers together thought leaders, scholars and operators of Xstrahl Small Animal Radiation Research (SARRP) systems from all over the world.
BACKGROUND: To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery. However, complete occlusion post radiosurgery...
Modulation of the redox system in cancer cells has been considered a promising target for anti-cancer therapy. The novel MTH1 inhibitor TH588 proved tremendous potential in terms of cancer cell eradication, yet its specificity has been questioned by recent reports,...
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose...
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