PURPOSE: Meningiomas are a frequent tumor of the central nervous system. Although mostly benign, approximately 5% present as atypical or malignant tumors. Treatments for atypical meningiomas include gross total resection and radiotherapy, but about 33% of patients...
OBJECTIVE: Modern image-guided small animal irradiators like the Xstrahl Small Animal Radiation Research Platform (SARRP) are designed with ultrathin 0.15 mm Cu filters, which compared with more heavily filtrated traditional cabinet-style biological irradiators,...
PURPOSE: To evaluate the acute changes in leukocyte populations after focal irradiation and to assess the role of Interleukin-6 (IL6) in acute and late radiation injury. METHODS AND MATERIALS: Mice were surgically implanted with a radiopaque marker on the surface of...
OBJECTIVES: Small animal radiotherapy research platforms such as XStrahl's SARRP enable more precise irradiation of tumours and normal tissues in preclinical models of cancer. Using an orthotopic G7 glioblastoma (GBM) xenograft model we studied the impact of four...
BACKGROUND: Craniospinal irradiation (CSI) is a crucial component of treatment for medulloblastoma (MB), a brain tumor clinically stratified into prognostically distinct molecular subgroups. Preclinical models of clinically-relevant CSI offer the potential to study...
October 30th, 2018 – Xstrahl Medical, global leaders in superficial radiotherapy devices and advanced radiation research systems, has appointed Neil Madle as Commercial Director - Radiotherapy. Based at Xstrahl’s UK head office in Surrey, Madle will be responsible for...
There have been a growing number of studies combining radiotherapy with immunotherapy to enhance both local and metastatic tumor cell kill leveraging the immune-mediated abscopal effect. This abscopal effect can enable the killing of metastatic cells, distant from the...
Low dose radiotherapy is being increasingly used to treat benign syndromes, however long term impact studies on these low dose radiotherapy treatments has long been neglected. In their paper “The Erlangen Dose Optimization trial for low-dose radiotherapy of benign...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitizing agents...
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