Chemotherapy has been successfully used to reduce radiation dose and volume for most paediatric patients. However, because of the failure of chemotherapeutic agents to cross the blood-brain barrier and the lack of response of some brain tumours to these agents,...
OBJECTIVES: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response. MATERIALS AND METHODS: Early radiation...
Radiotherapy has long been advocated as an alternative treatment in early Dupuytren's disease, however independent analysis of its use has not been carried out before. In their paper “Radiotherapy in Dupuytren's disease: a systematic review of the evidence” Kadhum M,...
PURPOSE: The goal of this work was to design a realistic mouse phantom as a useful tool for accurate dosimetry in radiobiology experiments. METHODS: A subcutaneous tumor-bearing mouse was scanned in a microCT scanner, its organs manually segmented and contoured. The...
Bioluminescence imaging (BLI) is a non-contact, optical imaging technique based on measurement of emitted light due to an internal source, which is often directly related to cellular activity. It is widely used in pre-clinical small animal imaging studies (such as...
ABSTRACT: Evaluation of the consequences of low to moderate doses of ionizing radiation (IR) remains a societal challenge, especially for children exposed to CT scans. Appropriate experimental models are needed to improve scientific understanding of how exposure of...
Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, sepsis, and...
The radiosensitizing efficacy of gold is well established, and has often been tested on Xstrahl systems, such as investigated in the Xstrahl in Action: Gold nanoparticles as dose-enhancement agent for X-ray therapy of melanomas however, there remain several...
PURPOSE: To characterize a small plastic scintillator developed for high resolution, real-time dosimetry of therapy and imaging x-ray beams delivered by an image-guided small animal irradiator. MATERIALS AND METHODS: A 1 mm diameter, 1 mm long polystyrene BCF-60...
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