Area of Interest: Radiation Research
The radiosensitizing efficacy of gold is well established, however, there remain several significant barriers to the successful clinical translation of nano-sized gold particles (AuNPs). These barriers include: retaining stability in relevant biological sera,...
Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves to significantly higher doses. However, its exploration was hindered due to the limited and expensive beamtime at...
Many radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with other treatment modalities. Many more research...
BACKGROUND: Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image...
INTRODUCTION: Combined immune checkpoint blockade has led to rare autoimmune complications, such as fatal myocarditis. Recent approvals of several anti-programmed death 1 (anti-PD-1) drugs for lung cancer treatment prompted ongoing clinical trials that directly...
The consequences of low to moderate doses of ionizing radiation (IR), especially for children exposed to CT scans, remains a challenging scientific topic. So far, no proper experimental models are available to better comprehend the consequences of exposure of the...
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an...
Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens usually consisting of a mix of surgery, chemotherapy, radiotherapy, stem cell transplant, immunotherapy and retinoid therapy. However, because...
At the 2017 Annual Meeting of the American Society for Radiation Oncology (ASTRO) researchers announced the development of an efficient and reproducible method to deliver craniospinal irradiation to patient-derived xenograft in mouse models. Despite aggressive...
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