Meeting the needs of medical and biological research, the CIXD is a self-contained cabinet incorporating the irradiation chamber and system electronics in one enclosure. In addition to removing the health and safety burden associated with the use of radioactive sources, the Xstrahl CIXD provides a safer, simpler, and less costly alternative to radioisotope irradiators for radiation exposure studies. Composed of two X-ray tubes (one positioned on the top and one on the bottom of the enclosure) with the focal spot of one meter (39 inches) apart, the emission of photons in a parallel opposed fashion results in a homogenous distribution of the dose desired. This feature enables the researcher to stack cell culture plates and achieve homogenous bone marrow ablation in small animals. An adjustable specimen shelf is provided in the isocentre offering a dynamic radiation field. Alignment lasers can be incorporated for visual confirmation of the centre of the radiation field.
Access to the irradiation chamber is via two parallel sliding doors with CDRH compliant safety interlocks. A leaded glass window is integrated so the researcher can monitor any specimen from just outside the irradiator. Multiple user logins provide customisable settings specific for your experiment, and a remote diagnostics function enables quick technical support and programming assistance.
There have been over 90 articles published with the help of Xstrahl irradiator cabinets. For the full list of articles please click here to be directed to our publication resource page.
Bespoke commissioning of the cabinet based on your research needs in order to provide the most accurate dosimetry data for your research.
External: W-148 cm, D-104 cm, H-205 cm
Total Weight Shielded: Cabinet: 2200 kg
Treatment distances: 33.5, 50, or 16.5cm FSD
Maximum Field Size: 53.3 cm circle at 50 cm FSD
Tube Voltage: 20-220 kV
Tube Current: 0-25 mA
Maximum Power Output: 3 kW
Mobile Built on wheels for simple transport
Manual Stage Z direction manual movements
Control Interface Operates X-rays
The Xstrahl CIXD r-ray irradiator enables safe irradiation of in vitro and in vivo biological samples within a laboratory environment. Check out the rest of our Life Sciences range.
We have been using the CIX2 X-ray cabinet for some years for cell culture experiments, and it is one of the most frequently used machines in our lab. In my opinion, the x-ray irradiator is a great tool for the irradiation of cells in our research lab. The cabinet runs very stable and is easy to operate (even for non-experienced visitors) and offers all options needed for our research making it extremely user-friendly. The possibility to change the filters quickly and to work with different distances away from the x-ray tube markedly enlarges the spectrum of experiments, which can be performed, and the safety aspect is hereby a big advantage. Furthermore, the technical support of X-Strahl is an outstanding example of good customer service.
The irradiation devices developed by Xstrahl for radiobiological research, both in vitro and in vivo, certainly are of outstanding quality in this field of research. We use the Xstrahl SARRP system successfully for our in-vivo-research on orthotopic small animal tumour models. With this system we are able to mimic the clinical situation and especially irradiation in mice much more precisely and easier than in former times. So it helps us to make our research more reliable and more clinically relevant. From my point of view, the customer service provided by Xstrahl is close to perfect. All in all, the possibilities provided by Xstrahl's irradiation equipment, e.g to closely mimic the radiotherapeutic clinical routine in small animal models (CT-based treatment planning with the SARRP system) is absolutely outstanding.
Prior to acquisition of the SARRP we were left with an obvious and significant void in our pre-clinical arsenal to investigate existing and novel cancer therapies. The technological similarity of the SARRP with the medical systems in our clinic and availability of ongoing technical support from Xstrahl were decisive factors. The SARRP forms an integral part of our translational research pipeline and will greatly expand the capacity, potential and quality of our cancer and radiation research.
SARRP has really made a significant impact in our lab, the ability to accurately target small volumes with image guidance hasn’t been possible before and we are now constantly evolving our approaches to leverage the technology to its maximum potential. Clearly our ability to delivery clinically relevant radiotherapy treatments in preclinical models has taken a major step forward, it up to us as a research community to translate this to the next generation of clinical innovatives
We have found SARRP an extremely valuable resource for pre-clinical work in which we aim to mimic clinical treatment regimens as closely as possible. SARRP enables efficient, accurate and reproducible pre-clinical radiotherapy that is especially valuable for assessing drug-radiation combinations in realistic schedules. We have been very impressed by the user-friendly interface in MuriPlan, which is straightforward for users and can be interfaced with imaging modalities such as MRI and bioluminescence for optimised image-guided planning. SARRP has become central to our translational pipeline in radiation biology and comes with extremely good support and maintenance to take the stress out of running large pre-clinical experiments.