To present a novel method of tumor radiosensitization through Hsp27 knockdown using locked nucleic acid (LNA) and to investigate the role of Hsp27 in DNA double strand break (DSB) repair.
David M. Guttmann, Lori Hart, Kevin Du, Andrew Seletsky, Constantinos Koumenis
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Orthovoltage X-rays Exhibit Increased Efficacy Compared with Gamma-rays in Preclinical Irradiation
Amidst concerns of radiological terrorism, there are institutional initiatives to replace radionuclide sources with lower energy X-ray sources. As researchers transition, questions remain regarding whether the biological effects of gamma-rays may be recapitulated with...
