Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.

Expression of Y-box binding protein-1 (YB-1) is associated with tumor progression and drug resistance. Phosphorylation of YB-1 at serine residue 102 (S102) in response to growth factors is required for its transcriptional activity and is thought to be regulated by cytoplasmic signaling phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways. These pathways can be activated by growth factors and by exposure to ionizing radiation (IR). So far, however, no studies have been conducted on IR-induced YB-1 phosphorylation.

Mahmoud Toulany, Tim-Andre Schickfluß, Wolfgang Eicheler, Rainer Kehlbach, Birgit Schittek and H Peter Rodemann

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