We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Bringing Superficial Radiation Therapy into Your Dermatology Practice: A Personal Journey
Xstrahl, a global leader in the delivery of superficial and orthovoltage radiation therapy and preclinical radiation research systems, will feature Radiant™ Aura with XBeam treatment planning at the annual meeting of the American Academy of Dermatology (AAD), in Orlando, FL, from March 7-9, 2025 (Booth #2975).
