We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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SPOTLIGHT: Behind the Beam: Tips, Tricks, and Translational Research from the Karolinska Institutet X-ray Irradiation Core Facility
Access the highly anticipated Xstrahl SPOTLIGHT Session, "Behind the Beam: Tips, Tricks, and Translational Research from the Karolinska Institutet X-ray Irradiation Core Facility," on demand now. This essential recording is a must-watch for radiation researchers and...
