We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
Download Paper
Precise proton irradiation of the cardiac apex using the SARRP
In this video of the Spotlight series, Dr. Verginadis shares about his experience using the SARRP, specifically with proton irradiation of the cardiac apex. Dr. Verginadis works with the SARRP at the UPenn Department of Radiation Oncology, studying a variety of topics...
