We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Xstrahl to Feature New MuriSuite and Voxl at RadRes 2025 in San Juan, PR
Xstrahl, the leader in preclinical radiation research systems, will demonstrate SmART-RAD at the 70th Annual Meeting of the Radiation Research Society (RRS) at the Westin La Paloma Resort & Spa, in Tucson, AZ, Sept. 15-18.
