We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
Download Paper
Xstrahl Presented at the 11th Congress of Radiological Technologists of R. N. Macedonia
Xstrahl presented The role of radiation technologists as a radiotherapy treatment at the 11th Congress of Radiological Technologists of R. N. Macedonia
