We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Intuitive Advanced Radiation Planning for SARRP using SmART-XPS
SmART-XPS is a Monte Carlo based Treatment Planning Software developed and optimised for use on the SARRP platform. This webcast focuses on the intuitive yet advanced irradiation planning capabilities for the Xstrahl SARRP and highlights the roadmap for 2025 of new...