The hypothalamus is the central regulator of a broad range of homeostatic and instinctive physiological processes, such as the sleep-wake cycle, food intake, and sexually dimorphic behaviors. These behaviors can be modified by various environmental and physiological cues, although the molecular and cellular mechanisms that mediate these effects remain poorly understood. Recently, it has become clear that both the juvenile and adult hypothalamus exhibit ongoing neurogenesis, which serve to modify homeostatic neural circuitry. In this report, we share new findings on the contributions of sex-specific and dietary factors to regulating neurogenesis in the hypothalamic mediobasal hypothalamus, a recently identified neurogenic niche. We report that high fat diet (HFD) selectively activates neurogenesis in the median eminence (ME) of young adult female but not male mice, and that focal irradiation of the ME in HFD-fed mice reduces weight gain in females but not males. These results suggest that some physiological effects of high fat diet are mediated by the stimulation of ME neurogenesis in a sexually dimorphic manner. We discuss these results in the context of recent advances in understanding the cellular and molecular mechanisms that regulate neurogenesis in postnatal and adult hypothalamus.
Daniel A. Lee, Sooyeon Yoo, Thomas Pak, Juan Salvatierra, Esteban Velarde, Susan Aja, and Seth Blackshaw
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Xstrahl to Attend VCS and ASDS Conferences in Orlando
Xstrahl to Attend VCS and ASDS Conferences in Orlando: The recent hurricanes have affected so many, and the team at Xstrahl hopes that you and your family are safe. Our hearts go out to everyone as they face this difficult time ahead. Prior to the hurricanes, Xstrahl committed to attending two conferences in Orlando, FL this week, and organizers of the conferences have confirmed that they will still be happening. If you are attending either conference in Orlando, please visit our team to say hello. We’d love to meet you.