The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition can interfere with functional angiogenesis. We explored the potential cooperativity between Notch inhibition and ionizing radiation in delaying tumor growth.
Stanley K Liu, Saif A S Bham, Emmanouil Fokas, John Beech, Jaehong Im, Song Cho, Adrian L Harris and Ruth J Muschel
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Prevention of Radiation-Induced Bladder Injury
Pelvic radiotherapy (RT) can cause debilitating bladder toxicities. In the recent study, Prevention of Radiation-Induced Bladder Injury: A Murine Study Using Captopril, researchers sought methods to protect against and alleviate RT-induced late bladder injury. See details and the full study here.
