High-precision radiotherapy requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. In the study “BioXmark for high-precision radiotherapy in an orthotopic pancreatic...
Surgery is the gold standard for treating basal cell carcinomas (BCCs), however in cases of positive tumor margins or recurrent disease, postoperative adjuvant or salvaging therapy is prefered to achieve good local control. In their paper “Orthovoltage X-rays for...
The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with...
Radiation-induced erectile-dysfunction (RiED) is one of the most common side effects of radiation therapy and significantly reduces the quality of life of cancer patients. Approximately 50% of prostate cancer patients experience RiED within 3 to 5 years after...
Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. The Xstrahl small animal radiation research platform (SARRP) enables state-of-the-art...
Glioblastoma (GBM) is a hyper vascular malignant tumour with a poor prognosis. Despite the availability of current chemotherapy and targeted therapies in GBM, not many therapeutic benefits have been achieved due to GBM developing drug resistance. Most therapies have...
Cancer is a complex disease, with a variety of approaches available for its treatment. Treatment modalities are often combined to maximize response and to overcome the limitations of individual modalities when used alone. One such example is the combination of...
Accidental high-dose radiation exposure can result in mortality or severe morbidity through acute radiation syndrome (ARS). The early risk of death from ARS can be attributed mainly to radiation-induced gastrointestinal syndrome (RIGS). Currently, there are no readily...
Radiotherapy is a proven skin cancer treatment modality with cure rates comparable to surgery. To make sure of its effectiveness while being safe, it is necessary to provide conformal dose coverage at the target (tumour) while sparing the surrounding normal tissues....
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