In their study “Velocity-Based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform” Paul J. Black, Deborah R. Smith, et al, implement a Velocity-based image fusion and adaptive deformable...
Chemotherapy has been successfully used to reduce radiation dose and volume for most paediatric patients. However, because of the failure of chemotherapeutic agents to cross the blood-brain barrier and the lack of response of some brain tumours to these agents,...
Bioluminescence imaging (BLI) is a non-contact, optical imaging technique based on measurement of emitted light due to an internal source, which is often directly related to cellular activity. It is widely used in pre-clinical small animal imaging studies (such as...
There have been a growing number of studies combining radiotherapy with immunotherapy to enhance both local and metastatic tumor cell kill leveraging the immune-mediated abscopal effect. This abscopal effect can enable the killing of metastatic cells, distant from the...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitizing agents...
Combined immune checkpoint blockade has led to rare autoimmune complications, such as fatal myocarditis. Recent approvals of several anti-programmed death 1 (anti-PD-1) drugs for lung cancer treatment prompted ongoing clinical trials that directly combine PD-1...
In many European countries, patients with a variety of chronical inflammatory diseases are treated with low-dose radiotherapy (LD-RT). In contrast to high-dose irradiation given to tumor patients, little is known about radiobiological mechanisms underlying this...
Cancer treatment has come a long way in a short time, however as new drugs and treatments are developed, the therapeutic index of treatments needs to be assessed. In their study “Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in...
Radiotherapy enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an increased...
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