OBJECTIVE Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and our aim was to develop a model of focal...
OBJECTIVE The mechanical and geometric accuracy of small animal image‐guided radiotherapy (SA‐IGRT) systems is critical and is affected by a number of system‐related factors. Because of the small dimensions involved in preclinical radiotherapy research, such factors...
Painful shoulder syndrome currently has a limited volume of treatments, however recent studies have suggested long term pain reduction could be a possible treatment. In their paper “The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder...
Esophageal cancer patients are mostly diagnosed in a locally advanced stage and treated with neoadjuvant chemoradiation followed by surgery. Prognosis is poor and response to treatment is highly variable. Identification of predictive imaging biomarkers is an important...
OBJECTIVES: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response. MATERIALS AND METHODS: Early radiation...
Radiotherapy has long been advocated as an alternative treatment in early Dupuytren's disease, however independent analysis of its use has not been carried out before. In their paper “Radiotherapy in Dupuytren's disease: a systematic review of the evidence” Kadhum M,...
PURPOSE: The goal of this work was to design a realistic mouse phantom as a useful tool for accurate dosimetry in radiobiology experiments. METHODS: A subcutaneous tumor-bearing mouse was scanned in a microCT scanner, its organs manually segmented and contoured. The...
ABSTRACT: Evaluation of the consequences of low to moderate doses of ionizing radiation (IR) remains a societal challenge, especially for children exposed to CT scans. Appropriate experimental models are needed to improve scientific understanding of how exposure of...
Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, sepsis, and...
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