OBJECTIVE Non-ablative or mild hyperthermia (HT) has been shown in preclinical (and clinical) studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most preclinical in vivo HT studies use subcutaneous tumor models which do not...
The orthovoltage x-ray energy frequently used in radiation research is prone to dosimetry errors due to insufficient backscatter conditions. In many radiobiology studies, especially for cell irradiations, precise dose calculation algorithms such as...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion...
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects...
January 31st, 2019 – Xstrahl Medical, global leader in superficial radiotherapy devices and advanced radiation research systems, has been named the best specialty radiotherapy systems manufacturer in the 2018 Global Health & Pharma Awards. Xstrahl manufactures...
OBJECTIVE Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and our aim was to develop a model of focal...
OBJECTIVE The mechanical and geometric accuracy of small animal image‐guided radiotherapy (SA‐IGRT) systems is critical and is affected by a number of system‐related factors. Because of the small dimensions involved in preclinical radiotherapy research, such factors...
Painful shoulder syndrome currently has a limited volume of treatments, however recent studies have suggested long term pain reduction could be a possible treatment. In their paper “The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder...
Esophageal cancer patients are mostly diagnosed in a locally advanced stage and treated with neoadjuvant chemoradiation followed by surgery. Prognosis is poor and response to treatment is highly variable. Identification of predictive imaging biomarkers is an important...
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