INTRODUCTION: Combined immune checkpoint blockade has led to rare autoimmune complications, such as fatal myocarditis. Recent approvals of several anti-programmed death 1 (anti-PD-1) drugs for lung cancer treatment prompted ongoing clinical trials that directly...
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an...
In the present study, we address the important issue of whether B-cells protected from irradiation-induced cell death, may survive with elevated levels of DNA damage. If so, such cells would be at higher risk of gaining mutations and undergoing malignant...
The ultimate goal of radiation therapy has always been to eradicate tumors locally while preventing damage to the surrounding tissue. New technologies aim to make treatment even more precise, while allowing clinicians to better plan treatment strategies and adapt to...
Carcinomas of the skin are the most accessible cancers, the diagnosis is readily made and the limits of the lesion are usually easy to define. No single treatment method is best for all cancers of the skin. If the sole criterion of success is eradication of the...
As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitising agents...
The governor of the Astrakhan region Alexander Zhilkin visited the oncology dispensary, where the newest equipment appeared, which allows treating a disease widespread in the hot Astrakhan climate - skin cancer. Skin cancer ranks first among all malignant neoplasms in...
BACKGROUND AND PURPOSE: High-precision radiotherapy (RT) requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. The purpose of this study is to establish a pancreatic...
PURPOSE: Despite recent advances in the treatment of metastatic prostate cancer, survival rates are low and treatment options are limited to chemotherapy and hormonal therapy. Although ionizing radiation is used to treat localized and metastatic prostate cancer, the...
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