PURPOSE: The goal of this work was to develop and test a cylindrical tissue-equivalent quality assurance (QA) phantom for micro computed tomography (microCT) image-guided small animal irradiators that overcomes deficiencies of existing phantoms due to its mouse-like...
The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. In a previous paper by Nile DL, Rae...
The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. In their paper “Importance of dosimetry...
Although small animal image-guided radiotherapy (SA-IGRT) systems are used increasingly in preclinical research, tools for performing routine quality assurance have not been optimized and are not readily available. Robust, efficient, and reliable quality assurance...
In their study “Improved Overall Survival of Mice by Reducing Lung Side Effects After High-Precision Heart Irradiation Using a Small Animal Radiation Research Platform” Sievert W, Stangl S, Steiger K, Multhoff G aim to reduce radiation exposure of the lung in...
The orthovoltage x-ray energy frequently used in radiation research is prone to dosimetry errors due to insufficient backscatter conditions. In many radiobiology studies, especially for cell irradiations, precise dose calculation algorithms such as...
In their study “MicroCT imaging dose to mouse organs using a validated Monte Carlo model of the small animal radiation research platform (SARRP)” Johnstone CD and Bazalova-Carter M, establish imaging dose to mouse organs with a validated Monte Carlo (MC) model of the...
Binding of the apolipoprotein E (ApoE)-containing lipoprotein complex to the low-density lipoprotein receptor (LDLR) is essential for cholesterol and lipid homeostasis. Inherited abnormalities in ApoE or LDLR function result in early onset cardiovascular disease and...
In their study “Dosimetric characterization of a single crystal diamond detector in X-ray beams for preclinical research” Severin Kampfer, Nathan Cho Stephanie E. Combs, Jan J.Wilkens, investigated a single crystal diamond detector, the microDiamond detector from PTW,...
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